Clinical trials

6

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Postoperative or Salvage Radiotherapy (RT) for Node Negative Prostate Cancer Following Radical Prostatectomy

The purpose of this study is to see what effects, good and/or bad, proton radiation, and/or conventional radiation and hormonal therapy (if applicable), has on prostate cancer that has already returned or the risk of prostate cancer returning.

Participants needed: 70
Trial details
Age: 18+Biological sex: MaleType: InterventionalSponsor: Proton Collaborative GroupUpdated: Jun 17, 2026Locations: 6
Eligibility criteria

Prostate cancer treated primarily with open, laparoscopic or robotically assiste... [+1]

Evidence of distant metastasis (M1). [+5]

Status: Recruiting

Conventionally Fractionated vs. Hypofractionated Comprehensive Nodal Irradiation for Breast Cancer Using Pencil Beam Scanning Proton Therapy

The purpose of this research study is to learn more about the effects of using proton radiation therapy delivered over a shorter course of treatment (3 weeks) compared with a longer, standard course of treatment (5 weeks) for women with breast cancer who require radiotherapy to the breast/chest wall and regional lymph nodes.

Participants needed: 276
Trial details
Phase: Phase 3Age: 19+Biological sex: FemaleType: InterventionalSponsor: Proton Collaborative GroupUpdated: Sep 9, 2025Locations: 7
Eligibility criteria

Patients with Stage I-III breast cancer who have undergone breast conserving sur... [+8]

Presence of skin ulceration and / or ipsilateral satellite nodules and/or edema... [+11]

Status: Recruiting

Proton Radiation for Unresectable, Borderline Resectable, or Medically Inoperable Carcinoma of the Pancreas

The prognosis for patients with localized pancreatic adenocarcinoma who are not surgical candidates is poor. Patients characterized as having "borderline resectable" disease treated with preoperative chemo-radiotherapy fair somewhat better - although many of these patients are not converted to resectability. It may be argued that intensification of local and regional therapy might 1.) Increase the share of patients able to undergo curative surgery and 2.) Improve the local disease control interval and extend survival for patients who remain unresectable. Therefore, the purpose of this research study is to determine if an increase in the number of surgical resection pancreatic adenocarcinoma is higher than historical data by using a combined treatment of proton radiation with capecitabine (oral chemotherapy).

Participants needed: 60
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Proton Collaborative GroupUpdated: Sep 9, 2025Locations: 4
Eligibility criteria

Biopsy proven unresectable adenocarcinoma of the pancreas. [+8]

Evidence of distant metastasis. [+5]

Status: Recruiting

Phase II Protocol of Proton Therapy for Partial Breast Irradiation in Early Stage Breast Cancer

The purpose of this research study is to compare the effects (good and bad) on women and their cancer using proton radiation therapy. This study is being done to see if proton radiation therapy will prove to be beneficial for women with early stage breast cancer. A clinical study is necessary to compare the results (good or bad) of proton radiation therapy.

Participants needed: 132
Trial details
Phase: Phase 2Age: 50+Biological sex: FemaleType: InterventionalSponsor: Proton Collaborative GroupUpdated: Sep 9, 2025Locations: 9
Eligibility criteria

Must sign study-specific, IRB approved informed consent form prior to study entr... [+15]

Previous history of ipsilateral invasive breast cancer or DCIS. [+14]

Status: Recruiting

Hypo-fractionated Radiation Therapy With or Without Androgen Suppression for Intermediate Risk Prostate Cancer

The purpose of this study is to compare the effects, good and/or bad of two treatment methods on subjects and their cancer. Proton beam radiation therapy is one of the treatments for men with prostate cancer who have localized disease. The benefit of the combination with androgen suppression is not completely understood. This study will compare the use of hypofraction proton therapy (28 treatments) alone to proton therapy with androgen suppression therapy.

Participants needed: 192
Trial details
Phase: Phase 3Age: 18+Biological sex: MaleType: InterventionalSponsor: Proton Collaborative GroupUpdated: Sep 4, 2025Locations: 4
Eligibility criteria

Histologically confirmed prostate adenocarcinoma (within 365 days of randomizati... [+10]

Pelvic lymph nodes > 1.5 cm in greatest dimension unless the enlarged lymph node... [+10]

Status: Recruiting

Registry Study for Radiation Therapy Outcomes

The purpose of this research study is to collect and analyze information from patients being treated with various forms of radiation therapy.

Participants needed: 40,000
Trial details
Biological sex: AllType: ObservationalSponsor: Proton Collaborative GroupUpdated: Sep 9, 2025Locations: 29Duration: 30 Years
Eligibility criteria

Planned treatment with radiation therapy [+1]