Health Trials

Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)

This is a sub-study of Study RM-493-040 (NCT05774756). The goal of this sub-study is to learn how well Setmelanotide works to improve weight reduction, hunger, and quality of life in patients 4 years of age and older with congenital Hypothalamic Obesity (cHO). To determine how well setmelanotide works and how safe it is, patients with cHO will take a daily injection of either setmelanotide or placebo and complete trial assessments for up to 26 weeks on a therapeutic regimen.

Participants needed: 39
Trial details
Phase: Phase 3Age: 4+Biological sex: AllType: InterventionalSponsor: Rhythm Pharmaceuticals, Inc.Updated: Feb 12, 2026Locations: 11
Eligibility criteria

Diagnosis of multiple pituitary hormone deficiency (MPHD), or septo-optic dyspla... [+3]

Diagnosis of Prader-Willi syndrome (PWS) or Rapid-onset obesity with hypoventila... [+11]

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Status: Recruiting

A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment

The purpose of this study is to evaluate the safety, tolerability, and PK of RM-718 in healthy subjects with obesity and in patients with MC4R Pathway Impairment

Participants needed: 150
Trial details
Phase: Phase 1, Phase 2Age: 12-65Biological sex: AllType: InterventionalSponsor: Rhythm Pharmaceuticals, Inc.Updated: Dec 22, 2025Locations: 7
Eligibility criteria

Male and female subjects in good health aged 18-55 years of age at Screening. [+14]

Any clinically significant abnormalities on screening laboratories or physical e... [+23]

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