Clinical trials

6

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

R-2487 in Patients With Rheumatoid Arthritis

The goal of this study is to determine the safety and tolerability of orally taken probiotic (R-2487) in patients with Rheumatoid Arthritis. Patients will take an oral dosage of probiotic (R-2487) and physicians will assess and measure their Rheumatoid Arthritis. Blood and fecal evaluations of inflammation and assessment of probiotic (R-2487) on fecal level will also be measured.

Participants needed: 73
Trial details
Phase: Phase 1Age: 18-75Biological sex: AllType: InterventionalSponsor: Rise Therapeutics LLCUpdated: Jun 12, 2026Locations: 6
Eligibility criteria

Ages 18-75 years (Inclusive). [+8]

Pregnancy (females, unless surgically sterile or at least two years post- menopa... [+35]

Status: Recruiting

R-3750 in Patients With Mild to Moderate Ulcerative Colitis

The goal of this study is to determine the safety and tolerability of orally taken probiotic (R-3750) in patients with mild to moderate ulcerative colitis. Patients will take an oral dosage of probiotic (R-3750) and provide patient-reported and physician scored measures of their colitis. Blood and fecal evaluations of inflammation and assessment of probiotic (R-3750) on fecal levels will also be measured.

Participants needed: 36
Trial details
Phase: Phase 1Age: 18-65Biological sex: AllType: InterventionalSponsor: Rise Therapeutics LLCUpdated: Jun 12, 2026Locations: 5
Eligibility criteria

18-65 years of age [+6]

Pregnancy, planned pregnancy, breastfeeding women [+17]

Status: Not yet recruiting

R-3750 in Patients With Late-Stage Acute Respiratory Distress Syndrome (ARDS)

The goal of this clinical trial is to learn if R-3750 is safe in \[in patients with late-stage, non-resolving Acute Respiratory Distress Syndrome (ARDS) . The main question\[s\] it aims to answer are: 1. the favorable safety profile 2. clinical improvement that includes reduced ventilator dependence and improved lung function. Participants will be given oral capsules daily and/or enteral nasogastric or orogastric (NG/OG tube) if necessary.

Participants needed: 20
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Rise Therapeutics LLCUpdated: Jun 12, 2026
Eligibility criteria

Age ≥18 years at the time of consent. [+13]

Age <18 years. [+25]

Status: Not yet recruiting

A Repeat Ascending Dosing Study of the Safety and Clinical Activity of R-3750 in Patients With Mild to Moderate COPD

The goal of this study is to determine the safety and tolerability of orally taken probiotic (R-3750) in patients with mild to moderate chronic obstructive pulmonary disease (COPD)

Participants needed: 27
Trial details
Phase: Phase 1Age: 40-82Biological sex: AllType: InterventionalSponsor: Rise Therapeutics LLCUpdated: Jan 29, 2026
Eligibility criteria

Subjects with a clinically documented history of COPD for at least 1 year in acc... [+8]

Patients whose treatment is considered palliative (life expectancy <12 months) C... [+19]

Status: Recruiting

R-5780-01 In Combination With PD-1 Checkpoint Inhibitors (Checkpoint Protein on Immune Cells Called T Cells) in Patients With Solid Tumors

The goal of this study is determine the safety and tolerability of orally taken probiotic (R-5780) in patients currently on a PD-1 Pathway Checkpoint Inhibitor (checkpoint protein on immune cells called T cells) with Solid Tumors.

Participants needed: 33
Trial details
Phase: Phase 1Age: 18-80Biological sex: AllType: InterventionalSponsor: Rise Therapeutics LLCUpdated: Sep 4, 2025Locations: 1
Eligibility criteria

At least 18 years of age to 80 [+6]

Any serious medical condition or laboratory abnormality or psychiatric condition... [+13]

Status: Not yet recruiting

R-2487 in Patients With Sjogren's Syndrome (SS)

The goal of this study is to determine the safety and tolerability of orally taken probiotic (R-2487) in patients with Sjogren's Syndrome. Patients will take an oral dosage of probiotic (R-2487) and physicians will assess and measure their Sjogren's Syndrome. Blood and fecal evaluations of inflammation and assessment of probiotic (R-2487) on fecal level will also be measured.

Participants needed: 36
Trial details
Phase: Phase 1Age: 18-80Biological sex: AllType: InterventionalSponsor: Rise Therapeutics LLCUpdated: Sep 4, 2025
Eligibility criteria

Diagnosis of SS according to American-European Consensus Group Criteria [+4]

No known active overlapping or associated other autoimmune disease [+11]