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Condition / disease
Location
Status: Not yet recruiting

A Comparative Effectiveness Study of Positive Airway Pressure (PAP) Therapy, Dental Device, and Atomoxetine-Oxybutynin for Treatment of Obstructive Sleep Apnea in Adults

Researchers want to identify which treatments for obstructive sleep apnea (OSA) work best and are easiest for patients to use consistently. Eligible participants will be randomly assigned one of three OSA treatments: traditional PAP therapy, a dental device, or a combination of two FDA-approved medications (atomoxetine and oxybutynin) that are currently approved for other conditions. Over the course of one year, participants will attend two in-person visits and take part in four phone check-ins to complete surveys, report any side effects, and discuss how well they are following their assigned treatment.

Participants needed: 2,400
Trial details
Phase: Phase 4Age: 18+Biological sex: AllType: InterventionalSponsor: Sairam ParthasarathyUpdated: Jul 1, 2026Locations: 4
Eligibility criteria

Obstructive sleep apnea (AHI >/= 5 per hour), diagnosed in the past 6 months [+3]

Prior treatment for OSA in past year [+14]