Health Trials

Clinical trials

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Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Phase 1 Study of HS-20093 Combinations in Patients With Extensive Stage Small Cell Lung Cancer

This is a Phase I clinical study of HS-20093. The purpose of this study is to evaluate the safety, tolerability, PK and efficacy of HS-20093 in combination with Adebrelimab in patients with Extensive Stage Small Cell Lung Cancer (ES-SCLC).

Participants needed: 50
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Shanghai Hansoh Biomedical Co., LtdUpdated: Jul 14, 2025
Eligibility criteria

Men or women aged more than or equal to (≥) 18 years. [+8]

Uncontrolled pleural effusion or ascites or pericardial effusion. [+8]

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Status: Recruiting

A Study of HS-20089 in Patients With Advanced Solid Tumors

HS-20089 is a novel DAR-6 antibody-drug conjugate （ADC） targeting B7-H4. In preclinical studies, it inhibited tumor cell growth expressing B7-H4 in vitro and in vivo. The first-in-human trial is conducted to assess the maximum tolerated dose (MTD) and dose limiting toxicity (DLT), to evaluate the pharmacokinetics, safety and preliminary anti-tumor activity of HS-20089 in Patients With Advanced Solid Tumors.

Participants needed: 177
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Shanghai Hansoh Biomedical Co., LtdUpdated: Apr 3, 2024Locations: 1
Eligibility criteria

Men or women aged more than or equal to (≥) 18 years [+6]

Previous or current treatment with drugs targeting B7-H4 [+11]

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