Health Trials

Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Study to Investigate HLA-G Targeted Exosome (SOB100) in Healthy Subjects

The investigational drug, SOB100, is an HLA-G targeted exosome equipped with a nanobody namely anti-HLA-G VHH on the exosome membrane. This is a Phase I dose escalation study to exam the tolerability, safety, and pharmacokinetics in healthy subjects.

Participants needed: 15
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Shine-On Biomedical Co., Ltd.Updated: Jan 26, 2026Locations: 1
Eligibility criteria

Male or female subjects aged ≥ 18 years old [+3]

With known or suspected to be hypersensitivity to HLA-G related treatment. [+7]

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Status: Recruiting

A Study to Investigate Safety and Preliminary Efficacy of SOA101 in Adult Subjects With Advanced Solid Tumors

The investigational drug, SOA101, is a nanobody-based trispecific antibody T cell engager targeting PD-L1/HLA-G/CD3. This is a Phase I/IIa study including dose-escalation, dose optimization and dose expansion parts to exam safety, tolerability, pharmacokinetics, immunogenecity and efficacy of SOA101 on advanced or metastatic solid tumor treatment.

Participants needed: 76
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Shine-On Biomedical Co., Ltd.Updated: Nov 6, 2025Locations: 1
Eligibility criteria

Male or female subjects aged ≥ 18 years old. [+10]

Active bacterial, fungal, viral OR atypical infection requiring systemic medicat... [+6]

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