Status: Not yet recruiting

Parcel-guided rTMS for Major Depressive Disorder

Study comparing standard repetitive transcranial magnetic stimulation (rTMS) for Depression to a novel targeting approach using brain surface parcellation to locate a specific brain target.

Participants needed: 60

Trial details

Phase: Phase 2Age: 18-60Biological sex: AllType: InterventionalSponsor: Soterix MedicalUpdated: Dec 18, 2025

Eligibility criteria

DSM-5 diagnosis of major depressive disorder confirmed using the Mini Internatio... [+2]

Ever met criteria for a psychotic disorder (Sz, SzAff, Bipolar disorder) [+14]

Status: Not yet recruiting

Ketamine Biomarker Validation

We will be developing an EEG-based biomarker for the effects of ketamine infusion in patients with Depression. We will be analyzing the effects of ketamine infusion on Depression symptoms and EEG signals.

Participants needed: 20

Trial details

Phase: Phase 1Age: 18-59Biological sex: AllType: InterventionalSponsor: Soterix MedicalUpdated: Dec 29, 2025Locations: 1

Eligibility criteria

Physically healthy patients who meet DMS-5 criteria for a major depressive episo... [+1]

Lifetime history of bipolar disorder, schizoaffective disorder, schizophrenia, o... [+7]

Status: Recruiting

Transcranial Direct Current Stimulation for Depression

This study will test the efficacy of transcranial direct current stimulation (tDCS) combined with mindfulness, remotely-delivered using a telemedicine protocol in 25 adults with unipolar depression.

Participants needed: 25

Trial details

Age: 22+Biological sex: AllType: InterventionalSponsor: Soterix MedicalUpdated: Nov 10, 2025Locations: 1

Eligibility criteria

Clinically stable patients that meet criteria for diagnosis of MDD according to... [+5]

Failure to respond to at least 2 antidepressant medications [+10]

Clinical trials

Parcel-guided rTMS for Major Depressive Disorder

Ketamine Biomarker Validation

Transcranial Direct Current Stimulation for Depression