Clinical trials

9

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Study of TYK-01054 Capsules in Patients With Advanced Solid Tumors

This study is to evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of the TEAD inhibitor TYK-01054 capsules in patients with locally advanced or metastatic advanced solid tumors

Participants needed: 219
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: TYK Medicines, IncUpdated: Dec 22, 2025Locations: 1
Eligibility criteria

Male or female subjects ≥18 years old [+7]

Presence of pleural effusion, pericardial effusion, or ascites that, in the inve... [+6]

Status: Not yet recruiting

Study of TYK-00540 Combined With Enzalutamide in Patients With Metastatic Castration-resistant Prostate Cancer(mCRPC)

This study is to evaluate the safety, and preliminary antitumor activity of TYK-00540 combined with Enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) that have failed novel endocrine therapy

Participants needed: 48
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: MaleType: InterventionalSponsor: TYK Medicines, IncUpdated: Aug 5, 2025Locations: 1
Eligibility criteria

Age ≥18 years. [+11]

Those who have previously received selective CDK2, CDK4 inhibitors, CDK4/6 inhib... [+23]

Status: Not yet recruiting

Study of TY-302 Capsules Combined With Abiraterone in Patients With Metastatic Castration-resistant Prostate Cancer(mCRPC)

This study is to evaluate the safety, and preliminary antitumor activity of TY-302 combined with Abiraterone tablets in patients with metastatic castration-resistant prostate cancer (mCRPC) that have failed novel endocrine therapy

Participants needed: 48
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: MaleType: InterventionalSponsor: TYK Medicines, IncUpdated: Aug 5, 2025Locations: 1
Eligibility criteria

Age ≥18 years. [+7]

Received CDK4/6 inhibitors (e.g., Palbociclib, Ribociclib, Abemaciclib, Trilacic... [+34]

Status: Recruiting

Study of TYK-00540 Tablets in Patients With Advanced Solid Tumors

This study is to evaluate the safety, pharmacokinetics, and preliminary antitumor activity of TYK-00540 as monotherapy or combined with fulvestrant in advanced solid tumors.

Participants needed: 180
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: TYK Medicines, IncUpdated: Apr 29, 2025Locations: 2
Eligibility criteria

Histologically or cytologically confirmed locally advanced/metastatic solid tumo... [+16]

Known hypersensitivity to any excipient of TYK-00540 or contraindication to fulv... [+15]

Status: Not yet recruiting

A Study of TY-9591 With Chemotherapy as 1st Line Treatment in Patients With Mutated Epidermal Growth Factor Receptor NSCLC

This study was a parallel, randomized, multicenter phase II clinical trial to evaluate the efficacy and safety of TY-9591 combined with platinum-based chemotherapy as first-line treatment in patients with locally advanced or metastatic non-small cell lung cancer harboring EGFR sensitive mutations.

Participants needed: 60
Trial details
Phase: Phase 2Age: 18-80Biological sex: AllType: InterventionalSponsor: TYK Medicines, IncUpdated: Dec 30, 2024
Eligibility criteria

Male or female ≥18 years old and <80 years old. [+8]

Previous treatment with any EGFR-TKI was performed. [+13]

Status: Recruiting

TY-9591 in the Patients With EGFR Mutations in Advanced NSCLC With Brain Metastases

This study is to evaluate the efficacy and safety of TY-9591 in first-line treatment of patients with EGFR-sensitive mutation-positive non-small cell lung cancer with brain metastases compared to Osimertinib.

Participants needed: 420
Trial details
Phase: Phase 2Age: 18-80Biological sex: AllType: InterventionalSponsor: TYK Medicines, IncUpdated: Nov 21, 2024Locations: 1
Eligibility criteria

Male or female aged ≥18 years and <80 years. [+11]

Previous treatment with EGFR inhibitor; [+23]

Status: Recruiting

A Study of TYK-00540 in Adult Patients With Solid Tumors

The primary objective of this study is to evaluate the safety and tolerability of TYK-00540, with dose-escalation stage and dose-expansion stage.

Participants needed: 156
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: TYK Medicines, IncUpdated: Feb 7, 2024Locations: 1
Eligibility criteria

Age ≥18 years. [+10]

Known allergy to any excipients of TYK-00540 tablets (for combination-agent esca... [+17]

Status: Recruiting

Phase III Study of TY-9591 in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (FLETEO)

To assess the efficacy and safety of TY-9591 versus Osimertinib in patients with locally advanced or Metastatic Non Small Cell Lung Cancer.

Participants needed: 680
Trial details
Phase: Phase 3Age: 18-80Biological sex: AllType: InterventionalSponsor: TYK Medicines, IncUpdated: Jan 30, 2024Locations: 2
Eligibility criteria

Male or female aged ≥18 years and <80 years. [+10]

Previous treatment with EGFR inhibitor; [+22]

Status: Recruiting

A Study of TY-2699a in Patients With Locally Advanced or Metastatic Solid Tumors

This is a phase I, multicenter, open-label study. The study will investigate the safety, tolerability, PK, and preliminary efficacy of TY-2699a on locally advanced or metastatic solid tumors.

Participants needed: 156
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: TYK Medicines, IncUpdated: Nov 7, 2023Locations: 2
Eligibility criteria

Be able to provide written informed consent approved by institutional review boa... [+3]

Concurrent participation in another interventional clinical trial, unless the pa... [+23]