Status: Recruiting
Tolerance Through Mixed Chimerism (Sip-Tego)
This is an open-label, single-institution study to assess the safety and the efficacy of the Sip-Tego regimen for the induction of donor-specific immunologic unresponsiveness to a renal allograft. The investigators propose to treat 6 adult subjects in end-stage renal disease (ESRD) who do not demonstrate evidence of prior sensitization.
Participants needed: 12
Trial details
Phase: Early Phase 1Age: 18-65Biological sex: AllType: InterventionalSponsor: Tatsuo Kawai, MD, PhDUpdated: Jun 8, 2026Locations: 1
Eligibility criteria
Male or female 18-65 years of age. [+7]
ABO blood group-incompatible renal allograft [+26]