Clinical trials

8

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension

MOMENTOUS is a multi-center, randomized study to prospectively evaluate the performance of an ECG-based AI device to predict whether participants with interstitial lung disease (ILD) are at high risk of undiagnosed pulmonary hypertension.

Participants needed: 900
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Tempus AIUpdated: Jul 2, 2026Locations: 30
Eligibility criteria

18 years or older at the time of consent [+3]

A known diagnosis of pulmonary hypertension (including patients prescribed a the... [+7]

Status: Recruiting

A Longitudinal Multi-Center Molecular Biomarker Discovery Registry for Patients With Hematologic Malignancies

The TEMPUS AQUARIUS Study is a non-interventional, longitudinal observational study focused on hematological malignancies. It will collect rich molecular (multi-omic) and clinical data from patient cohorts through serial blood draws and the acquisition of leftover tissue and/or bone marrow aspirates during their routine therapy and disease monitoring. The primary goal is to understand the association between biomarkers and real-world clinical outcomes in these patient populations.

Participants needed: 550
Trial details
Age: 0+Biological sex: AllType: ObservationalSponsor: Tempus AIUpdated: Jun 15, 2026Locations: 6Duration: 5 Years
Eligibility criteria

Willing and able to participate in the research and provide biospecimens [+10]

002A: Received prior treatment for follicular lymphoma [+4]

Status: Recruiting

Tempus Small Cell Lung Cancer Observational Study (Sculptor)

The study is a non-interventional evaluation of participants with extensive stage (ES) SCLC who will receive diagnostic and (where possible) post-progression tumor tissue profiling, alongside plasma ctDNA and CTC biomarker profiling during standard of care therapy in both first and second line treatment.

Participants needed: 200
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Tempus AIUpdated: Jun 15, 2026Locations: 11Duration: 3 Years
Eligibility criteria

Histologically confirmed small cell lung cancer diagnosis [+17]

Status: Recruiting

Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

For patients with breast cancer, it's important to find any remaining cancer cells after they've had their main treatment. Even a few cells, called minimal residual disease (MRD), can lead to the cancer coming back later. A way to find these cells is by looking for tiny bits of cancer DNA that are shed into the blood. This is called circulating tumor DNA (ctDNA). A simple blood test, often called a liquid biopsy, can detect this ctDNA. This research aims to see if finding this cancer DNA in the blood can help predict if a patient's cancer will return. It also may help find out if the treatment is working. Ultimately, the results of this research may help doctors better manage breast cancer and develop new and improved tests and treatments.

Participants needed: 900
Trial details
Age: 18-99Biological sex: AllType: ObservationalSponsor: Tempus AIUpdated: Jun 12, 2026Locations: 14
Eligibility criteria

Willing and able to participate in the research and provide biospecimens [+14]

Not willing or able to adhere with the study procedures [+2]

Status: Recruiting

A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

The study is a prospective, longitudinal, non-interventional, multicenter study of participants with HNSCC who will have tissue and blood based molecular biomarker profiling during their standard of care treatment.

Participants needed: 500
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Tempus AIUpdated: Jun 12, 2026Locations: 30Duration: 1 Year
Eligibility criteria

≥18 years of age [+4]

Non-squamous histologies (eg, nasopharynx or salivary gland) [+4]

Status: Recruiting

TEMPUS ARIES: A Biobank Registry Platform Study in Oncology

This study is a non-interventional, multicenter, multicohort evaluation of participants with cancer who will undergo longitudinal plasma ctDNA biomarker profiling at specific time points in addition to standard of care therapy.

Participants needed: 500
Trial details
Age: 18-99Biological sex: AllType: ObservationalSponsor: Tempus AIUpdated: Feb 24, 2026Locations: 32
Eligibility criteria

≥18 years of age [+3]

Status: Recruiting

GEMINI-NSCLC: NSCLC Biomarker Study

GEMINI NSCLC Study is a non-interventional study that will be collecting clinical and molecular health information from patients with NSCLC who will receive longitudinal blood collection in addition to their standard of care therapy and disease surveillance with the goals of identifying the molecular evolution of lung cancer with standard of care therapy, and determining the utility of ctDNA dynamics to predict risk of recurrence and therapeutic outcomes.

Participants needed: 1,200
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Tempus AIUpdated: Feb 5, 2026Locations: 58
Eligibility criteria

A known or suspected NSCLC treated with curative intent -(surgery with or withou... [+14]

Tumors that lack activating EGFR mutations (e.g., exon 19 deletion or exon 21 L8... [+10]

Status: Recruiting

Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays

The study is an observational multicenter evaluation of participants with colorectal cancer (CRC) who will receive longitudinal plasma ctDNA biomarker profiling in addition to their standard-of-care therapy and disease surveillance.

Participants needed: 300
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Tempus AIUpdated: May 6, 2025Locations: 20
Eligibility criteria

Known or suspected colorectal adenocarcinoma (Stage I to IVA disease) [+4]

Not willing to have additional blood samples collected [+1]