Clinical trials

The goal of this clinical trial is to learn if Emotion-Focused Therapy (EFT) works to reduce symptoms of Prolonged Grief Disorder (PGD) in adults. PGD happens when the pain of losing a loved one lasts a long time and causes serious problems in daily life. * The main questions this study aims to answer are: 1. Does EFT lower grief symptoms in adults with PGD? 2. Does EFT also help with related problems, such as anxiety, depression, trauma, and overall distress? * Who can take part: Adults (18 years or older) who lost a loved one at least 6 months ago and meet the criteria for PGD. \- What will happen in the study: Participants will be randomly assigned to one of two groups: 1. EFT group: 8 to 10 weekly, face-to-face therapy sessions with a trained therapist. 2. Self-help group: 10 weekly self-help exercises based on EFT, completed on their own. * All participants will complete questionnaires on grief, mood, and well-being before starting, during the study, at the end of treatment (12 weeks), and again at 5 months and 12 months after starting. * In the EFT group, the therapeutic relationship will also be measured during sessions 3 and 8. * Why this study is important: Most current treatments for grief are based on cognitive-behavioral therapy, but not everyone benefits from them. EFT is a promising therapy that focuses on emotions and has shown positive results for other mental health problems. This trial will test if EFT can be an effective treatment for people struggling with prolonged grief.

The goal of this clinical trial is to compare a combined intervention based on physical exercise, nutritional control, and individualized psycho-oncological support can achieve weight control and maintain adequate body composition in premenopausal women with localized BC with ER and/or PR expression who receive aLHRH in combination with TAM or AI as part of adjuvant treatment. The study's primary objectives are to evaluate the impact of the combined intervention on weight reduction and favorable modification of body composition in terms of reduction in body fat and increase in lean mass. The secondary objectives aim to evaluate the impact of the combined intervention program on CRF, heart rate (HR), capillary lactate levels, upper and lower body strength, physical functionality, and patient-reported outcomes (PROs). (exercise level, asthenia, self-perception, anxiety and depression), blood count and biochemistry values that could be modified, nutritional situation, and side effects of treatments.