Clinical trials

This study is testing a new liquid treatment for people with long-lasting (chronic) wounds, such as venous leg ulcers or diabetic foot ulcers. These wounds can be difficult to heal because they often contain dead tissue and bacteria. The new product is designed to help clean the wound and remove dead tissue, which may help the wound heal better. It will be compared to a commonly used treatment called Polyhexanide gel. About 80 people aged 60 years or older will take part in this study. Each participant will be randomly assigned (like flipping a coin) to receive either the new treatment or the standard treatment. Neither the participant nor most of the study team will know which treatment is being used during the study to ensure fair results. The study will last 4 weeks. Participants will attend eleven visits at the wound care center. During these visits, trained nurses will clean and treat the wound. The study team will: * Measure the size of the wound * Take small samples from the wound to check for bacteria * Ask questions about pain and general health * Check blood flow in the legs * Perform blood tests at the beginning A specialist doctor will examine the wound at the start and at the end of the study to see how it has improved. Overall, this study aims to find out if the new treatment can help wounds heal better and more quickly than current standard care. Taking part in the study is completely voluntary. Participants can leave the study at any time without affecting their usual medical care. All personal and medical information will be kept confidential.

The goal of this clinical trial is to evaluate the effectiveness of a digital psychoeducational intervention, "What Were We Thinking" (WWWT), to prevent the development of postpartum depression and anxiety symptoms in first-time mothers in Chile. The study includes adult women with a healthy, full-term infant younger than two months who are receiving care in primary health centers. The main questions it aims to answer are: * Does participation in the WWWT intervention reduce depressive and anxiety symptoms at 3 months after the end of the intervention compared to usual care? * Does participation in the intervention improve maternal self-efficacy, perceived social support, and coparenting relationship quality compared to usual care? Researchers will compare an experimental group receiving the full WWWT intervention with a control group receiving usual care to determine the effectiveness of the intervention. Participants will: * Complete self-report questionnaires assessing depressive symptoms, anxiety symptoms, maternal self-efficacy, perceived social support, and coparenting at baseline and at 3-month follow-up * Be randomly assigned to either the intervention group or the control group * Receive the WWWT intervention between 4 and 10 weeks postpartum (intervention group), including: * Fourteen psychoeducational video modules (3-5 minutes each) delivered via text messaging over 4-5 weeks * Individual contact with a trained facilitator through text messaging * One virtual group session with other mothers and a facilitator * Continue receiving usual care in primary health services (control group) and receive a shortened version of the intervention after the follow-up assessment

Stigma towards people with mental health problems is a serious public health problem that limits access to treatment and social participation, in addition to being considered the main barrier to inclusion and quality of health care. This stigma also affects students and health professionals, impacting the quality of care and help seeking in mental health. In this context, it is necessary to develop innovative and effective interventions among university students to reduce this stigma and promote an inclusive and recovery-based approach. The aim of the present research project is to analyze the effect of a mentoring program on levels of stigma and mental health help-seeking intention in psychology and nursing students. This three-session mentoring program is based on experiential learning and has been validated and adapted to our country. The mentors, professionals with lived experience in mental health, will provide knowledge and experiences to the students through direct contact sessions in the classroom, focusing especially on the processes of recovery and self-determination. Research question: What is the effect of a mentoring program on levels of stigma and mental health help-seeking intention in health care students? Within the dependent variables of the study are the measurement of levels of stigma and mental health help-seeking intention in students. The independent variables will be the type of group (experimental and control), age, gender and career. Methodology: Quantitative study, including the participation of health students in the experimental and control groups. The sample size was determined using the G\*Power software. After approval by the institutional ethics committee and signature of the informed consent of the participants, the mentoring program will be implemented in the classroom. For this purpose, the levels of stigma and intention to seek mental health help in both groups will be measured using nationally and internationally validated instruments, before, after and at 4 weeks. Data analysis will be performed using a mixed ANOVA model to compare pre- and post-intervention outcomes between the two groups. The present study will provide valuable evidence on the effectiveness of mentoring-based interventions in reducing stigma in health care students, a key group in the future provision of care for people with mental health problems. The results will also lay the groundwork for larger-scale studies to assess the impact of the intervention in other groups and settings, with the potential to significantly improve the quality of care and well-being of patients and their families.

The goal of this clinical trial is to test the efficacy of laser photobiomodulation in adult hematologic cancer patients undergoing hematopoietic stem cell transplantation (HSCT). The main questions it aims to answer are: • Is photobiomodulation with laser in the oral cavity, compared to standard care, effective in preventing oral mucositis and functional impairments in adult patients receiving HSCT? • What is the level of patient´s acceptability of photobiomodulation with laser in the oral cavity during HSCT? Participants once a day will receive photobiomodulation (diode laser device) in their oral cavity from the first day of transplantation conditioning until third day post-transplant. Researchers will compare with usual care to see if photobiomodulation helps preventing oral mucositis and functional impairment.