Clinical trials

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Condition / disease
Location
Status: Not yet recruiting

Phase II/III Randomized Trial of UC-MSC Secretome vs Sodium Hyaluronate in Knee Osteoarthritis

This study is a randomized, double-blind, multicenter Phase II/III clinical trial designed to evaluate the effectiveness and safety of umbilical cord-derived mesenchymal stem cell (UC-MSC) secretome compared with sodium hyaluronate in patients with knee osteoarthritis. Knee osteoarthritis is a common degenerative joint disease that causes chronic pain and functional limitation. Participants will be randomly assigned to receive intra-articular injections of either UC-MSC-derived secretome or sodium hyaluronate. The study aims to assess improvements in knee pain, physical function, and overall clinical outcomes, as well as to evaluate the safety of the interventions over the study period.

Participants needed: 50
Trial details
Phase: Phase 2, Phase 3Age: 40-70Biological sex: AllType: InterventionalSponsor: Universitas SriwijayaUpdated: May 12, 2026Locations: 1
Eligibility criteria

Diagnosed with primary OA in one or both knees based on American College of Rheu... [+6]

Participants who, based on physical examination and clinical history (anamnesis)... [+15]