Clinical trials

The aim of this study is to investigate whether there are differences in muscle activation of the First Dorsal Interosseous (FDI) and the Abductor Pollicis Longus (APL) between individuals with and without trapeziometacarpal osteoarthritis (TMC OA) of the thumb during the performance of six activities of daily living (ADLs). The FDI has been defined as a key stabilizer of the TMC joint of the thumb. However, the literature reports limited information on FDI and APL activation during ADLs. TMC OA of the thumb can cause pain, decreased thumb strength, impaired hand function, and difficulty performing ADLs. Understanding muscle activation patterns during these activities is essential to comprehend how this condition affects hand function and to guide more specific and effective rehabilitation strategies. Participants will perform six ADLs: turning a key to open, turning a key to close, picking up a coin, writing, squeezing a tube of toothpaste, and holding a glass of water. Muscle activity will be recorded using surface electromyography (sEMG) during all tasks. Adults aged 30 years and older, both men and women, with TMC osteoarthritis and healthy controls without osteoarthritis will be invited to participate. Researchers will measure the activation patterns of the FDI and APL muscles during the ADLs, with the aim of identifying differences between both groups and providing evidence to guide the rehabilitation of patients with thumb base osteoarthritis.

This study examines how the characteristics and performance of virtual assistants influence user experience in service settings. Approximately 400 adults will interact with virtual assistants presented as avatars, chatbots, or voice assistants in simulated tourism, cultural, retail, or financial service situations. Participants will be exposed to one or more experimental conditions that may differ in features such as communication style, language specificity, anthropomorphism, personalization, type of virtual assistant, level of immersion, or the presence of inaccurate responses or errors. After the interaction, participants will complete questionnaires about their perceptions, emotions, trust, satisfaction, acceptance of recommendations, and intention to use the virtual assistant. During the experimental session, non-invasive methods may be used to measure visual attention and psychophysiological responses. These methods include eye tracking, electrodermal activity, electroencephalography, and automated facial expression analysis. Facial recordings will be used to analyze emotional expressions and will not be used to identify participants. The study does not involve drugs, biological products, medical treatments, diagnostic procedures, or investigational medical devices. Its purpose is to improve scientific understanding of human interaction with artificial intelligence and virtual assistants in service environments.

448 kHz capacitive-resistive monopolar radiofrequency is an emerging physiotherapy technique whose usefulness and clinical relevance still need to be investigated. This study is a pre-post quasi-experimental study in which several variables will be measured before and immediately after 448 kHz capacitive resistive monopolar radiofrequency. It aims to analyze the morphological and mechanical changes in the Achilles tendon following the intervention in healthy runners.

The main aim of this study is to analyse the effect of a preventive exercise program (INSPIRE: Indoor Sports Injury Prevention) on the lower-limb injuries in adolescent futsal players. For this purpose, 26 adolescent futsal players will be recruited, and after baseline evaluation, they will be randomized either the standard care, that will undergo the standard strengthening program developed each year in their team, or the experimental group, that will undergo the INSPIRE program, based on three stages (motor control, strength and endurance, and propioception and neural workout). Both groups will develop a 8-week intervention. Regarding the evaluation, the participants will have three evaluations: baseline, 4 weeks, and 8 weeks, and they will complete validated questionnaries (Overuse Injury Questionnaire, and Return to Play Score), together with functional tests (Y-Balance Test), strength testing using a dynamometer, and motor control testing using force plates.

This randomized controlled trial aims to evaluate the effectiveness of immersive virtual reality (VR)-based Action Observation Therapy (AOT) as an adjunct to conventional rehabilitation in patients with traumatic wrist and hand injuries. Participants will receive standard rehabilitation treatment, and the intervention group will additionally undergo a six-week VR program involving observation and execution of functional hand and wrist movements. Outcomes related to hand function, grip strength, pain, proprioception, disability, and psychological factors will be assessed to determine the potential benefits of incorporating VR into rehabilitation programs.

The goal of this clinical trial is to evaluate whether a multicomponent nurse-led intervention (BEST CARE ICTUS\_HC) can reduce stroke-related complications and improve recovery in adults (18 years and older) hospitalized with an acute ischemic or hemorrhagic stroke in hospitals without specialized Stroke Units. The main questions it aims to answer are: 1. Does the implementation of the program increase the early and correct detection of swallowing difficulties (dysphagia) to prevent pneumonia? 2. Does the program reduce the severity of attention problems (hemineglect) and improve the patients' quality of life up to 6 months after discharge? Researchers will compare patients receiving the BEST CARE ICTUS\_HC program to patients receiving usual hospital care to see if this new approach improves patient safety and long-term functional recovery. Participants will: * Receive either the usual hospital care for stroke or the BEST CARE ICTUS\_HC nursing program, depending on the study phase of the hospital. * Be screened for swallowing problems using a standardized test before receiving any food or drink. * Be cared for in an adapted environment (FLECHA Project) that uses visual signs and room organization to help with orientation and safety. * Have their temperature, blood sugar, and blood pressure monitored under a strict specialized protocol. * Be contacted by phone 30 days and 6 months after leaving the hospital to answer questions about their health and quality of life.

This study is a randomized clinical trial that will compare two surgical techniques for patients with knee osteoarthritis and varus deformity who are candidates for medial opening wedge high tibial osteotomy. The goal is to evaluate whether using patient-specific 3D-printed surgical guides improves the accuracy of the bone cut compared with the conventional technique performed with anatomical landmarks and fluoroscopy. A total of 50 adult patients will be randomly assigned to one of two groups: conventional osteotomy or osteotomy assisted by patient-specific instrumentation (PSI). The main outcome is the accuracy of the osteotomy cut, measured by comparing preoperative planning with the postoperative CT scan. Secondary outcomes include leg alignment, surgical time, radiation exposure, complications, and functional recovery assessed with validated questionnaires (KOOS, WOMAC, IKDC, EQ-5D) and gait analysis using depth cameras. Patients will be followed for up to 12 months after surgery to evaluate clinical and radiological outcomes.

The present study try to evaluate the effectivenness of an early intervention program based on multimodal physiotherapy and focused on therapeutic exercise to improve the results of patients with a reverse shoulder phrostesis. This trial will be a randomized controlled trial with parallel groups, and outcomes variables will include psychometric properties through the use of specific questionnaries, and laboratory variables such as strength with a dynamometer, range of movement with a goniometer, muscle mass with an ultrasound, and kinematic parameters with inertial sensors. This study aims to develop an original intervention program in order to try to establish new protocols in the management of these patients.

This randomized controlled trial will evaluate the effects of a 12-week foot and ankle strengthening program on physical function and health-related quality of life in menopausal women. Menopause is associated with hormonal changes that may negatively affect muscle strength, balance, and functional capacity, potentially leading to reduced mobility and increased risk of falls. Although exercise interventions have demonstrated benefits in this population, most programs focus on global lower-limb training and rarely target the foot and ankle complex, which plays a key role in postural stability and gait propulsion. Approximately 60 menopausal women aged 45-65 years will be randomly assigned to either an intervention group performing a structured foot and ankle strengthening program or a control group maintaining their usual physical activity. The intervention will last 12 weeks and will include one supervised weekly session and four home-based sessions. The primary outcome will be ankle plantarflexion isometric strength measured by hand-held dynamometry. Secondary outcomes will include ankle strength in other directions, intrinsic foot muscle function, gait speed, spatiotemporal gait parameters, balance, foot-related functional status, and health-related quality of life.

The aim of this study is to investigate whether there are differences in muscle activation of the First Dorsal Interosseous (FDI) and the Abductor Pollicis Longus (APL) between individuals with and without trapeziometacarpal osteoarthritis (TMC OA) of the thumb. The study also seeks to identify which exercises are most effective for activating these muscles, in order to inform rehabilitation strategies for patients. The FDI has been defined as a key stabilizer of the thumb TMC joint. However, the literature reports various protocols for FDI activation and limited information on APL behavior during these exercises. OA TMC of the thumb can cause pain, decreased thumb strength, impaired hand function, and difficulty performing activities of daily living (ADLs). Appropriate rehabilitation is essential to maintain muscle function, limit joint degeneration, and improve hand performance; however, the exercises that optimally activate the FDI and APL muscles are not yet established. Participants will perform a series of standardized exercises and functional tasks designed to activate the FDI and APL muscles. Exercises include FDI strengthening with elastic bands in different hand positions (palmar and ulnar support), as well as exercises with the thumb in greater abduction. Functional tasks simulating everyday activities (e.g., turning a key, picking up a coin, writing, squeezing a tube of toothpaste, and holding a glass of water) will also be performed. Muscle activity will be recorded using surface electromyography (sEMG) during all tasks. Adults aged 40 years and older, both men and women, with TMC osteoarthritis and healthy controls without osteoarthritis will be invited to participate. Researchers will measure the activation patterns of the FDI and APL muscles during the exercises and functional tasks. The study aims to identify exercises that optimally activate these muscles, providing evidence to guide the rehabilitation of patients with thumb base osteoarthritis.

This study aims to evaluate the efficacy, safety, and feasibility of a home-based auricular transcutaneous vagus nerve stimulation (tVNS) program in Health Sciences university students with poor sleep quality. Participants will be randomly assigned (1:1) to receive either active auricular stimulation (cymba conchae/tragus) or a control stimulation applied to the earlobe. The intervention will be self-administered at home using a low-frequency TENS-like device for 60 minutes per session, 5 sessions per week for 3 weeks. Sleep quality will be primarily assessed using the Pittsburgh Sleep Quality Index (PSQI) before and after the intervention. Secondary outcomes include insomnia severity, daytime sleepiness, perceived stress, anxiety, quality of life, and psycho-academic outcomes.

Children and adolescents with chronic pain often lack a proper diagnosis and treatment. Research has shown that, if left untreated, it usually doesn't resolve and continues through adulthood. The goal of this multi-phase study is to co-develop (with patients), test, and implement a smartphone app called "Digital Solution for Pain in Adolescents" (Digital SPA) which can provide pain management resources to children with chronic pain and their parents, preventing future disability. Participants will: participate in individual and group interviews, respond to questionnaires online and try a smartphone app.

This project aims to analyze the use of neuromodulation within a treatment protocol for musculoskeletal conditions of the upper limb, as well as to determine the difference between two and three sessions per week. Study participants will be divided into four intervention groups: the first will receive two sessions per week for a period of six months, while the second will receive three sessions per week for the same period. The treatment protocol will consist of therapeutic physical exercise focused on the muscles and joints of the lower limb, stretching of the involved muscles, and neuromodulation of the brachial plexus nerve root, which innervates the affected structures. The third and fourth intervention groups will receive the same treatment as mentioned above, but without neuromodulation. The third group will receive three sessions per week, while the second group will receive two sessions per week. Two different types of measurement variables will be used: objective variables will be used to measure range of motion and muscle strength. Subjective variables will also be used through validated questionnaires, covering physical activity, health-related quality of life, upper limb function, and a visual analog scale for pain perception.

This project aims to analyze the use of neuromodulation within a treatment protocol for musculoskeletal conditions of the lower limb, as well as to determine the difference between two and three sessions per week. Study participants will be divided into four intervention groups: the first will receive two sessions per week for a period of six months, while the second will receive three sessions per week for the same period. The treatment protocol will consist of therapeutic physical exercise focused on the muscles and joints of the lower limb, stretching of the involved muscles, and neuromodulation of the nerve root of the lumbosacral plexus, which innervates the affected structures. The third and fourth intervention groups will receive the same treatment as mentioned above, but without neuromodulation. The third group will receive three sessions per week, while the second group will receive two sessions per week. Two different types of measurement variables will be used: objective variables will be used to measure range of motion and muscle strength. Subjective variables will also be used through validated questionnaires, covering physical activity, health-related quality of life, lower limb function, and a visual analog scale for pain perception.

This project aims to analyze the use of hyperthermia within a treatment protocol for plantar fasciitis, as well as to determine the difference between two and three sessions per week. Study participants will be divided into four intervention groups: the first will receive two sessions per week for a period of six months, while the second will receive three sessions per week for the same period. The treatment protocol will consist of therapeutic physical exercise focused on the foot muscles and stretching the plantar fascia and posterior chain, hyperthermia on the plantar fascia insertion area in the calcaneus and adjacent areas, and the use of an orthotic insole used for walking. The third and fourth intervention groups will receive the same treatment as mentioned above, but without hyperthermia. The third group will receive three sessions per week, while the second group will receive two sessions per week. Two different types of measurement variables will be used: objective variables will be used to measure local pain using an algometer, assess ankle joint range of motion, and use ultrasound imaging techniques. Subjective variables will also be used through validated questionnaires, which will address physical activity, perceived functional limitations in patients with lower limb pathologies, lower limb functional assessment, and a visual analogue scale for pain perception.

This project aims to analyze the use of hyperthermia within a bursitis treatment protocol, as well as to determine the difference between two and three sessions per week. Study participants will be divided into four intervention groups: the first will receive two sessions per week for a period of six months, while the second will receive three sessions per week for the same period. The treatment protocol will consist of therapeutic physical exercise focused on the affected joint, stretching of the involved muscles, and the application of hyperthermia to the bursa and surrounding areas. The third and fourth intervention groups will receive the same treatment as mentioned above, but without hyperthermia. The third group will receive three sessions per week, while the second group will receive two sessions per week. Two different types of measurement variables will be used: on the one hand, the objective variable will be measurement and assessment of the bursa using ultrasound imaging. Subjective measurement variables will also be used through validated questionnaires, which will address physical activity, perceived functional limitations, and the visual analog scale for pain perception.

The development of an integral and global treatment to improve the quality of life in those withType II Diabetes Patients is challenging, thus a whole body Photobiomodulation (PBM) therapy program is proposed as an effective option.

Spastic Hemiparetic Cerebral Palsy (SHCP) uses to limit the manual function. Using anodic transcranial direct current stimulation, it is possible to activate certain cerebral areas depending on where the electrodes are. This study will use this kind of stimulation on the contralateral primary motor cortex of the affected upper limb and analyze the effects.

This project aims to analyze the use of hyperthermia within a treatment protocol for Carpal Tunnel Syndrome (CTS), as well as to determine the difference between two and three sessions per week. Study participants will be divided into four intervention groups: the first will receive two sessions per week for a period of six months, while the second will receive three sessions per week for the same period. The treatment protocol will consist of therapeutic physical exercise focused on the hand flexor muscles and neural stretching, the application of hyperthermia to the carpal tunnel and adjacent areas, and the use of a night splint. The third and fourth intervention groups will receive the same treatment as mentioned above, but without hyperthermia. The third group will receive three sessions per week, while the second group will receive two sessions per week. Two different types of measurement variables will be used: objective variables will be used to measure hand flexor muscle strength and wrist free range of motion. Subjective variables will also be used through validated questionnaires covering physical activity, perceived functional limitations, upper limb functional assessment, neuropathic pain, and a visual analogue scale for pain perception.

The goal of this randomized clinical trial is to compare how the incorporation of Virtual Reality could influence in proprioception, kinesiophobia, functionality and catastrophism in people that are undergoing a rehabilitation treatment after a wrist fracture. The principal questions it aims to answer are: * Evaluate the effect of using virtual reality added to standard rehabilitation of wrist injuries in proprioception impairment. * Evaluate the effect of using virtual reality on psychological factors as kinesiophobia and catastrofism. * Evaluate the effect of using virtual reality in functionality on wrist-injured patients. Intervention will be: * Control group: participants of this group will receive conventional rehabilitation of the wrist, plus a specific proprioceptive exercise program. * Experimental group: participants of this group will receive the same treatment as the control group but adding virtual reality games at the end of the session. Researchers will compare control and experimental group to see if an implantation of Virtual Reality could had benefits on function, kinesiophobia, catastrofism and proprioception.

The objective of this study is 1) to study the acute and chronic effect of resistance therapeutic physical exercise (RTPE) in the prevention of breast cancer-related lymphedema (BCRL) in breast cancer survivors at risk using variables related to the lymphatic response; 2) Study the possible relationship between changes in body composition at a local and regional level and volume changes produced by RTPE in patients at risk of suffering from BCRL.