Clinical trials

The goal of this clinical trial is to learn whether creatine supplementation changes how the body adapts to repeated exercise in the heat in healthy recreationally active adults and varsity athletes. The study will also examine whether creatine affects fluid balance, blood volume changes and exercise performance. The main questions it aims to answer are: Does creatine supplementation increase plasma volume and total body water during repeated heat exposure more than placebo? Does creatine supplementation improve exercise performance after heat acclimation more than placebo? Does creatine supplementation influence cardiovascular responses to heat stress? Researchers will compare a creatine supplementation group to a placebo group to determine whether creatine changes the magnitude of heat acclimation adaptations. Participants will: Complete baseline measurements of body composition, hydration, blood markers, and exercise performance. Consume either creatine monohydrate or a placebo supplement daily Complete repeated supervised exercise sessions in a controlled heated environment Undergo repeated assessments of body water, temperature, heart rate, and exercise performance throughout the study

Dialectical behavior therapy (DBT) is a comprehensive, third-wave psychological intervention designed for patients with complex and severe behavioral, emotional, and interpersonal dysfunction. DBT has since been adapted to shorter, briefer, "skills training" formats, which have been effective for a number of mild-to-moderate mental health conditions, including depression and anxiety. Moreover, internet-delivered formats of DBT (iDBT) have similarly started to build support for their effectiveness, although there are fewer studies on digital formats. One study found that over 12 weeks, iDBT was deemed acceptable (e.g., 50% of participants were still active after 4 weeks) and there were improvements in multiple symptom domains, such as depression, anxiety, suicidality, functional disability, as well as alcohol and substance dependence. In the current study, the investigators will examine the feasibility, acceptability, and potential efficacy of a new iDBT intervention, packaged as an online e-learning skills course, with adult participants. The study is a pilot trial as iDBT has never been tested in this format through formal research. Thus, this pilot study aims to examine whether this course is usable, practical, and potentially useful to others in the future. The investigators will recruit up to 40 individuals with mild-to-moderate depression and anxiety for an 8-week study. Following a phone screen to determine eligibility, participants will complete a baseline session where they will provide consent, complete a brief interview and questionnaires, and register for the e-learning skills course. Over the course of 8 weeks, participants will be exposed to material adapted from a DBT manual in a self-guided manner. Participants will complete follow-up assessments at 4 and 8 weeks.

The goal of this clinical trial is to learn if mindfulness meditation can improve closure and emotion towards unresolved memories in an undergraduate student population. This will be tested through a brief, novel intervention called Mindful Recollection, where participants transition immediately from mindfulness meditation into the recollection of an unresolved memory. The secondary aim of the study is to investigate the mechanisms of change underlying Mindful Recollection. Overall then, the main questions this study aims to answer are: * Does mindful recollection reduce negative emotions associated with unresolved event memories? * Can increases in acceptance, decentering, and reappraisal account for the observed effects of mindful recollection on negative emotion? * Does mindful recollection facilitate closure towards unresolved event memories? * Can increases in acceptance, decentering, and reappraisal account for the observed effects of mindful recollection on closure? Researchers will compare the Mindful Recollection intervention to a mind-wandering control task to see if mindfulness meditation uniquely produces positive changes in emotion and closure above and beyond placebo. Mindful Recollection will involve a 13-minute audio-guided mindfulness meditation followed immediately by 2 minutes of memory recollection. The control task will involve 13-minutes of audio-guided mind-wandering followed immediately by 2 minutes of memory recollection. Participants will: * Complete pretest measures of emotion and closure towards an unresolved event memory. * Engage in either the Mindful Recollection intervention or the placebo control task after a 24-72 hour delay. * Complete post-test measures of emotion and closure towards the same unresolved event memory.