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Condition / disease
Location
Status: Recruiting

Renal Pelvic Denervation Pilot Trial

The RPD Pilot trial will evaluate the safety and effectiveness of Verve Medical's RPDTM renal denervation system for hypertensive patients with uncontrolled blood pressure despite use of two medications at a therapeutic dose. The novelty of the RPDTM system relates to its placement via natural orifice into the renal pelvis (bilaterally) for delivery of radiofrequency energy to ablate the nerves that pass through the outer wall of the renal pelvis, a technique referred to as renal pelvic denervation (RPD).

Participants needed: 60
Trial details
Age: 21-80Biological sex: AllType: InterventionalSponsor: Verve Medical, IncUpdated: Jan 8, 2026Locations: 5
Eligibility criteria

Currently taking 2 anti-hypertensive medications (NOTE: no changes to medication... [+4]

History of non-compliance with medical care or medical treatments. [+46]