Clinical trials

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Condition / disease
Location
Status: Not yet recruiting

Doxycycline vs. Macrolide for MRMP (DOMINO)

The goal of this clinical trial is to learn if doxycycline works to treat pneumonia in children. It focuses on children with Mycoplasma pneumoniae infection that may not respond to standard medicines. The main questions it aims to answer are: * Does doxycycline stop fevers faster than azithromycin? * Is doxycycline safe for children, specifically regarding tooth color changes? Researchers will compare doxycycline to azithromycin to see if doxycycline works better to treat this type of pneumonia. Participants will: * Take either doxycycline or azithromycin by mouth for 7 to 14 days. * Check their body temperature to see when their fever goes away. * Visit the hospital to check for any medical problems. * Have their teeth checked for color changes 28 days after starting the medicine.

Participants needed: 208
Trial details
Phase: Phase 4Age: 3-17Biological sex: AllType: InterventionalSponsor: Young June ChoeUpdated: Dec 29, 2025Locations: 14
Eligibility criteria

Age: 3 to 17 years at the time of enrollment. [+4]

Prior use of tetracyclines, macrolides, or quinolones for the current illness. [+4]