7T Anatomo-functional Characterization of Structures in the Action Observation Network
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age11-40
SponsorIRCCS Fondazione Stella Maris
About this trial
The goal of this study is to explore the anatomical-functional characteristics of the AON circuit (with particular interest for subcortical areas and the cerebellum), and the cortico-subcortical connectivity of the nodes of the AON circuit, using an ultra-high field (7T), high spatial resolution Magnetic Resonance Imaging protocol.
The main questions it aims to answer are:
* Can we demonstrate the involvement of subcortical areas and cerebellum in the AON circuit in each single-subject? * Can we obtain similar results in a small group of patients with Cerebral Palsy (CP), in order to demonstrate the feasibility of this approach for the study of the mechanisms of AON reorganization, after early brain damage? * Are different patterns of functional activation correlated to different clinical characteristics of CP patients?
Participants will perform a 7 Tesla MRI scan, with a functional and anatomical dedicated protocol and will have a comprehensive clinical assessment before the MRI exam.
Eligibility criteria
Qualifiers
Patients with pre-, peri- or post-natal brain injury, documented by a previous MRI examination of the brain;
Intellectual development within the norm or within the mild deficit area, to guarantee understanding and cooperation in the 7T fMRI study;
Understanding of the Italian language;
Disqualifiers
Contraindications to performing the 7T fMRI exam;
Neuropsychiatric comorbidity that precludes collaboration in the 7T fMRI study;
Lack of capacity to understand and to will;
Pregnancy;
Trial design
Treatments tested in this trial
- 7T MR exam
- clinical assessment
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
IRCCS Fondazione Stella Maris
Lead sponsor
University of Parma
Collaborator
Fondazione IMAGO7
Collaborator
Source ClinicalTrials.gov