This randomized clinical trial compares postoperative pain and MMP-9 levels after root canal treatment of necrotic teeth with apical periodontitis, using either single-visit or two-visit instrumentation. The primary outcome is pain intensity measured at multiple intervals using a Visual Analogue Scale. The secondary outcome is the periapical expression of MMP-9 assessed via ELISA. The trial aims to determine whether treatment timing impacts inflammation and healing.
Age between 18-40 years.
Males/Females.
Non-Vital pulps.
Negative response to cold pulp tester (ethyl chloride spray*).
Medically compromised patients having significant systemic disorders. (ASA III or IV).
Teeth with swelling or fistulous tract.
Teeth with acute or chronic periapical abscess.
Mobility Grade II or III.
Marwa Hisham Mohamed Salah Eldin
Lead sponsor
Cairo University
Sponsor institution