Status: Not yet recruiting
A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulps With Apical Periodontitis in One or Two Visits
This randomized clinical trial compares postoperative pain and MMP-9 levels after root canal treatment of necrotic teeth with apical periodontitis, using either single-visit or two-visit instrumentation. The primary outcome is pain intensity measured at multiple intervals using a Visual Analogue Scale. The secondary outcome is the periapical expression of MMP-9 assessed via ELISA. The trial aims to determine whether treatment timing impacts inflammation and healing.
Participants needed: 28
Trial details
Age: 18-40Biological sex: AllType: InterventionalSponsor: Marwa Hisham Mohamed Salah EldinUpdated: Aug 3, 2025
Eligibility criteria
Age between 18-40 years. [+11]
Medically compromised patients having significant systemic disorders. (ASA III o... [+7]