BATTLE study has been designed as a prospective, multi-center, randomized, controlled trial. This study will enroll 83 patients with chronic heart failure accompanied by intraventricular block (NICD) over an estimated recruitment period of 3 years. An LOT-CRT group will be compared with a group of conventional BiVP in the follow-up of at least 6 months. The study aimed to compare the curative effect of LOT-CRT in preserving LV systolic function with traditional BiVP in chronic heart failure patients with NICD.
Ischemic or non ischemic cardiomyopathy
Optimal medical therapy for at lest 3 months
NYHA class II-IV
LVEF≤35% as assessed by echocardiography
Valvular heart disease that requires or has undergone surgical intervention
After mechanical tricuspid valve replacement
Persistent or permanent atrial fibrillation or atrial flutter
Second or third degree atrioventricular block
The First Affiliated Hospital with Nanjing Medical University
Lead sponsor
Shanghai Zhongshan Hospital
Collaborator
Sir Run Run Shaw Hospital
Collaborator
Fu Wai Hospital, Beijing, China
Collaborator
West China Hospital
Collaborator
The First Affiliated Hospital of Dalian Medical University
Collaborator
The First People's Hospital of Yunnan
Collaborator
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Collaborator
Guangdong Provincial People's Hospital
Collaborator
Shanghai Tong Ren Hospital
Collaborator
Fujian Provincial Hospital
Collaborator
Fujian Medical University Union Hospital
Collaborator