To observe and study the clinical effect of Huperzine A Injection on reducing postoperative delirium in elderly patients undergoing non-cardiac surgery
≥ 75 years old.
Comply with the indication of non-cardiac surgery under general anesthesia.
Anesthesia grade of American Society of Anesthesiologist (ASA) as III~IV grade.
The estimated operation time ≥ 2 hours.
Patients with impaired renal function (Cr is 1.5 times higher than the upper limit of the normal value of the central laboratory) or abnormal liver function (Alanine aminotransferase(ALT) and Aspartate aminotransferase(AST) are 2 times higher than the upper limit of the normal value of the central laboratory).
Patients who are positive for infectious diseases.
Patients accompanied with central nervous system injury.
Patients with previous history of delirium and epilepsy, long-term use of psychoactive drugs or preoperative assessment of delirium.
Second Affiliated Hospital of Wenzhou Medical University
Lead sponsor
Affiliated Wenling Hospital of Wenzhou Medical University
Collaborator