A Study on the Modulation of Gut Microbiota by Oral Sialic Acid in Healthy Subjects
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorXiaolong Li
About this trial
This is a single-center prospective cohort study conducted by the Department of General Surgery at the Second Affiliated Hospital of Army Medical University (Xinqiao Hospital). The purpose of this study is to explore and clarify the effects of sialic acid intervention on gut microbiota structure, with a focus on the proliferation of pathogens (e.g., Escherichia coli, Klebsiella pneumoniae), and to develop novel prevention and treatment strategies for improving intestinal homeostasis.
Eligibility criteria
Qualifiers
Aged between 18 and 75 years
No history of major diseases, no previous surgical history, and no history of cardiometabolic diseases (such as hypertension, diabetes mellitus, obesity, etc.)
No use of drugs that may affect gut microbiota or metabolic function (e.g., antibiotics, probiotics, immunosuppressants, etc.);
Voluntarily participate in the study and sign the informed consent form.
Disqualifiers
Comorbidities: Complicated with other severe diseases (e.g., immunodeficiency, chronic liver disease, renal insufficiency, malignant tumors, etc.).
Recent infections: Registration records indicate a history of severe infections in the recent period (within 3 months) or currently receiving anti-infective treatment.
Special populations: Pregnant women, lactating women, or women planning to become pregnant.
Poor compliance: Volunteers who are unable to cooperate with the study protocol or follow-up
Trial design
Treatments tested in this trial
- Oral Sialic acid
Treatment groups
42 Participants
are divided into 1 treatment groupSponsors and collaborators
Xiaolong Li
Lead sponsor
Army Medical University, China
Sponsor institution
Source ClinicalTrials.gov