A Study on the Peripheral Blood in Patients With Acute Coronary Syndrome

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorSecond Affiliated Hospital of Wenzhou Medical University

About this trial

The goal of this study is to conduct analyses the changes of cell growth factors, inflammatory factors, metabolites, plasma proteome, etc. in the blood of patients with ACS (acute coronary syndrome), as well as their correlations with the disease prognosis, based on multi-omics or other related research methods. The main questions it aims to answer are:

The growth factors that have significant changes in the peripheral blood of the ACS population, especially fibroblast growth factors? Inflammatory factors and chemokines related to the onset of ACS? The metabolites and proteins that are significantly altered in the peripheral blood after the onset of ACS? Researchers will compare ACS population to CCS (Chronic Coronary Syndrome) population, and control group (patients without coronary artery stenosis, valvular heart disease, structural heart disease, or any other kind of cardiomyopathy).The peripheral venous blood from the participants will be collected within 24 hours after their admission to the hospital.

Eligibility criteria

Qualifiers

cTn>99th ULN or CK-MB>99th ULN

ST-segment elevation with a convex upward morphology

in conjunction with one or more of the following conditions: persistent ischemic chest pain; echocardiographic evidence of abnormal segmental ventricular wall motion; or abnormal coronary angiography findings.

cTn>99th ULN or CK-MB>99th ULN

Disqualifiers

Lactating or pregnant women

Patients with malignant neoplasms

Severe hepatic/renal dysfunction

Severe hematological disorders

Trial design

Treatments tested in this trial

  • Not listed

Trial groups

310 Participants
are grouped into 3 trial groups

Sponsors and collaborators

Second Affiliated Hospital of Wenzhou Medical University

Lead sponsor

The Central Hospital of Lishui City

Collaborator