The aim of the study is to compare clinical outcomes between direct oral anticoagulant (DOAC) monotherapy versus dual antithrombotic therapy (DOAC plus clopidogrel) in patients with atrial fibrillation and acute myocardial infarction after percutaneous coronary intervention (PCI).
Patients aged 19 years old
Patients with AF and CHA2DS2-VA score ≥2.
ST-segment elevation myocardial infarction (STEMI) or Non-ST-segment elevation myocardial infarction (NSTEMI)
STEMI: ST-segment elevation ≥0.1 mV in ≥2 contiguous leads or documented newly developed left bundle-branch block.12
Patients contraindicated for use of DOACs or clopidogrel
Mechanical prosthetic valve or moderate-to-severe mitral stenosis requiring vitamin K antagonist
Planned cardiac surgery within 1 year after randomization
Patients with severe thrombocytopenia or coagulopathy