The goal of this study is to evaluate the feasibility and preliminary efficacy of a combined acupuncture and exercise intervention for the management of chemotherapy-induced peripheral neuropathy (CIPN) in participants with metastatic bladder cancer receiving enfortumab vedotin (EV) and pembrolizumab (Pembro).
The names of the two study groups in this research study are:
* Acupuncture + Virtual Exercise (AVE) * Virtual Exercise Only (VE)
Age ≥ 18 years old
Diagnosed with pathologically proven advanced or metastatic urothelial cancer (mUC)
Planning to receive treatment with EV-Pembro or have received up to two cycles of EV-Pembro treatment with enrollment occurring prior to the start of the third cycle
Self-reported ability to walk for 6 minutes and/or 2 blocks
History of peripheral neuropathy prior to EV-Pembro initiation
Patients with a pacemaker or other electronically charged medical device; or
Participate in more than 60 minutes of moderate or vigorous structured exercise/week
Adults unable to consent