ADAPT Forward - Master Protocol of a Platform Study to Evaluate the Safety and Efficacy of Multiple Regimens in Participants With Myasthenia Gravis

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
Sponsorargenx

About this trial

ADAPT Forward is a platform study with the aim to look at how safe different drugs are and how well they work for people with myasthenia gravis. The goal is to find the best therapeutic approach to reduce patients' side effects and improve their quality of life.

Eligibility criteria

Qualifiers

Is at least 18 years of age and the local legal age of consent for clinical studies

Has been diagnosed with MG with consistent clinical features per the investigator's clinical judgment

If receiving MG therapy, including nonsteroidal immunosuppressive drugs (NSIDs), corticosteroids, or acetylcholinesterase (AChE) inhibitors either in combination or alone, the participant should receive a stable dosage before master protocol screening

Disqualifiers

Known autoimmune disease or any medical condition other than the indication under study that would interfere with an accurate assessment of clinical symptoms of MG or puts the participant at undue risk

Is MGFA (Myasthenia Gravis Foundation of America) Class V

Trial design

Treatments tested in this trial

  • Efgartigimod IV
  • Empasiprubart IV

Treatment groups

70 Participants
are divided into 1 treatment group

Sponsors and collaborators