AChR-Ab Seropositive Generalized Myasthenia Gravis

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Review clinical trials related to AChR-Ab Seropositive Generalized Myasthenia Gravis. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

ADAPT Forward 2 - ISA2 - a Study to Evaluate the Safety, Tolerability and Efficacy of Empasiprubart IV Monotherapy in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis

This study is part of the ADAPT Forward platform study (NCT07294170). ADAPT Forward is a platform study with the aim to look at how safe different drugs are and how well they work for people with myasthenia gravis. The goal is to find the best therapeutic approach to reduce patients' side effects and improve their quality of life. The aim of this ISA2 is to investigate the effects of empasiprubart in participants with AChR-Ab seropositive generalized myasthenia gravis (gMG). The ADAPT Forward master protocol is registered on https://clinicaltrials.gov/study/NCT07294170

Participants needed: 40
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: argenxUpdated: Jun 29, 2026
Eligibility criteria

Is seropositive for anti-acetylcholine receptor antibodies (AChR-Ab). [+2]

Clinical diagnosis of systemic lupus erythematosus (SLE). [+3]

Status: Recruiting

ADAPT Forward - Master Protocol of a Platform Study to Evaluate the Safety and Efficacy of Multiple Regimens in Participants With Myasthenia Gravis

ADAPT Forward is a platform study with the aim to look at how safe different drugs are and how well they work for people with myasthenia gravis. The goal is to find the best therapeutic approach to reduce patients' side effects and improve their quality of life.

Participants needed: 70
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: argenxUpdated: Jun 12, 2026Locations: 18
Eligibility criteria

Is at least 18 years of age and the local legal age of consent for clinical stud... [+2]

Known autoimmune disease or any medical condition other than the indication unde... [+1]

Status: Recruiting

ADAPT Forward 1 - ISA1 - a Study to Evaluate Empasiprubart IV as add-on Therapy to Efgartigimod IV in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis With a Partial Clinical Response to Efgartigimod

This study is part of the ADAPT Forward platform study (NCT07294170). ADAPT Forward is a platform study with the aim to look at how safe different drugs are and how well they work for people with myasthenia gravis. The goal is to find the best therapeutic approach to reduce patients' side effects and improve their quality of life. The aim of this ISA1 is to evaluate the safety and therapeutic relevance of empasiprubart as add-on therapy to efgartigimod in participants with AChR-Ab seropositive generalized myasthenia gravis. The ADAPT Forward master protocol is registered on https://clinicaltrials.gov/study/NCT07294170

Participants needed: 70
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: argenxUpdated: Jun 12, 2026Locations: 15
Eligibility criteria

Is seropositive for anti-acetylcholine receptor antibodies (AChR-Ab) [+2]

Clinical diagnosis of systemic lupus erythematosus (SLE) [+3]