About this trial
This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure.
The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.
Eligibility criteria
Qualifiers
Adults with severe sepsis or septic shock on mechanical ventilation
Enrolled in the initial six hours of ICU admission
Disqualifiers
Patients with withdrawal or hospice order.
Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission.
Patients with COPD.
Patients transferred from outside ICU with ongoing sepsis management for more than six hours.
Trial design
Treatments tested in this trial
- Not listed