Appropriate Use of Blood Cultures in the Emergency Department Through Machine Learning

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAmsterdam UMC, location VUmc

About this trial

The goal of this clinical trial is to study whether the use of our blood culture prediction tool is non-inferior to current practice and if it can improve certain outcomes in all adult patients presenting to the emergency department with a clinical indication for a blood culture analysis (according to the treating physician). The primary endpoint is 30-day mortality. Key secondary outcomes are:

* hospital admission rates * in-hospital mortality * hospital length-of-stay. In the intervention group, the physician will follow the advice of our blood culture prediction tool.

In the comparison group all patients will undergo a blood culture analysis.

Eligibility criteria

Qualifiers

Age >= 18 years

Have a clinical indication for a blood culture analysis (according to the treating physician)

Have sufficient data recorded (laboratory results and vital sign measurements) for a prediction to be made (at least 20% of the needed parameters)

Disqualifiers

Central Venous Line (CVL) or Peripherally Inserted Central Catheter (PICC) in situ

Neutrophil count < 0.5 * 109/L

Candidemia or S. aureus bacteraemia in the past 3 months.

Most likely diagnosis of endocarditis/spondylodiscitis/infected prosthetic material

Trial design

Treatments tested in this trial

  • Blood culture prediction tool

Treatment groups

7,584 Participants
are divided into 2 treatment groups

Sponsors and collaborators