Basilar Artery Occlusion Chinese Endovascular Trial in Patients With Large Core Infarct
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorCapital Medical University
About this trial
This study evaluates the safety and efficacy of endovascular therapy for acute basilar artery occlusion with large core infarcts in a multicenter randomized trial.
Eligibility criteria
Qualifiers
Posterior circulation acute ischemic stroke within 24 hours from symptom onset/last seen well.
Occlusion (TIMI 0-1) of the basilar artery or intracranial segments of both vertebral arteries (V4) as evidenced by CTA/MRA/DSA.
Patients with large core infarction in the posterior circulation, defined as a posterior circulation Acute Stroke Prognosis Early CT score (pc-ASPECTS) score of 3-5 on CT angiography source images or MR with diffusion-weighted imaging or non-contrast CT.
Age ≥18 and ≤80 years.
Disqualifiers
Known hemorrhagic diathesis, coagulation factor deficiency, or oral anticoagulant therapy with INR > 3.0.
Baseline platelet count < 50000/µL.
Baseline blood glucose of < 50mg/dL or >400mg/dL.
Severe, sustained hypertension (SBP > 220 mm Hg or DBP > 110 mm Hg) NOTE: If the blood pressure can be successfully reduced and maintained below these levels using commonly used medications in China for these purposes (including iv antihypertensive drips), the patient can be enrolled.
Trial design
Treatments tested in this trial
- Endovascular Therapy Plus Best Medical Treatment
- Best Medical Treatment Alone
Treatment groups
314 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov