The goal of this clinical trial is to learn if brain stimulation can improve movement and daily function in people with multiple sclerosis (MS). The study will also look at how this treatment affects fatigue, sleep, memory and attention, and quality of life.
The main questions this study aims to answer are the following:
Does this treatment improve coordination and balance? Does it reduce fatigue and improve sleep and daily life? Does it change brain activity?
Researchers will compare active brain stimulation to sham stimulation (a look-alike treatment that does not deliver real stimulation) to see if the treatment works.
Participants will:
Receive brain stimulation sessions for two weeks Attend assessment sessions before and after treatment Return for a follow-up visit after four weeks Complete tests of movement, fatigue, sleep, and thinking
Confirmed diagnosis of Multiple Sclerosis according to the revised McDonald criteria
Adult Age > 18 years
Expanded Disability Status Scale (EDSS) score between 2.0 and 6.0
Clinically stable disease status for at least 3 months prior to enrollment
Multiple sclerosis relapse within the past 3 months
History of epilepsy or seizures
Presence of implanted electronic devices (e.g., pacemaker, neurostimulator)
Metallic implants in the head or skull incompatible with transcranial magnetic stimulation (TMS)