Goal: Investigate the health effects of electronic cigarettes (e-cigarettes) and whether a short break from using them can improve health.
Participants:
Up to 148 people (74 who use e-cigarettes and 74 who don't) Age and sex will be matched between the groups.
Study Design:
Two connected studies:
Observational Study: Compares general health (including lung function, heart health, blood pressure, and inflammation) of e-cigarette users to non-smokers.
Clinical Trial: E-cigarette users will be randomly assigned to either:
Take a 7-day break from e-cigarettes (intervention group) Continue using e-cigarettes as usual (control group) Both groups will have their health measured before and after the 7-day period. Main Outcome: How well your heart and lungs work during exercise.
Other Outcomes: Lung function, blood vessel function, risk factors for heart disease, and body measurements.
Why is this study important?
E-cigarettes are becoming more popular, but their health effects are unknown. This study will provide new information on whether e-cigarettes harm your health and if quitting for a short time can improve it.
This information can be used to create better public health policies about e-cigarettes.
14 years of age or older
Reporting using nicotine electronic cigarettes (e-cigarettes)
Serum cotinine levels equal to or greater than 3 ng/mL
Contraindications for maximum exercise testing or any of study procedures
Use of any smoking product except e-cigarette (combustible cigarette, cigar, hookah, marijuana, etc.)