Cerebral Autoregulation in Patients With Symptomatic Cerebral Atherosclerotic Stenosis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorYi Yang
About this trial
In this multi-center prospective observational study within a cohort of symptomatic cerebral atherosclerotic stenosis (sCAS) patients, 850 subjects were planed to be enrolled to explore the relationship between cerebral autoregulation (CA) and stroke recurrence, determine the threshold values of CA parameter for predicting stroke recurrence associated with particular stenosis.
Eligibility criteria
Qualifiers
Age ranging from 18 to 80, both genders
Unilateral internal carotid artery (ICA) or M1 segment of middle cerebral artery (MCA) stenosis (rate of stenosis ranging from 50-99%)
Acute ischemic cerebrovascular events (TIA or ischemic stroke) within cerebral stenotic artery supplying area
Onset of disease <30 d before enrollment
Disqualifiers
Vertebral artery (VA), basilar artery (BA), anterior cerebral artery (ACA), or posterior cerebral artery (PCA) stenosis; Bilateral internal carotid artery (ICA) or M1 segment of middle cerebral artery (MCA) stenosis(rate of stenosis ranging from 50-99%)
Patients who have received or plan to undergo intravascular interventional treatment/endarterectomy
Other intracranial diseases, including cerebral hemorrhage (primary or secondary), intracranial neoplasm, aneurysm, arteriovenous malformation, etc.
Evidence for embolic stroke, such as atrial fibrillation, prosthetic valve surgery, and suspected endocarditis, etc.
Trial design
Treatments tested in this trial
- Cerebral autoregulation assessment
Treatment groups
850 Participants
are divided into 1 treatment groupSponsors and collaborators
Yi Yang
Lead sponsor
The First Hospital of Jilin University
Sponsor institution
Shenzhen Second People's Hospital
Collaborator
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Collaborator
The First Affiliated Hospital with Nanjing Medical University
Collaborator
The First Affiliated Hospital of University of South China
Collaborator
Eighth Affiliated Hospital, Sun Yat-sen University
Collaborator
The First Affiliated Hospital of Hebei North University
Collaborator
Qilu Hospital of Shandong University
Collaborator
The Affiliated Hospital of Qingdao University
Collaborator
The Affiliated Hospital of Yanbian University
Collaborator
Source ClinicalTrials.gov