Clinical trials

16

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Efficacy and Safety of Plasma Adsorption Combined With EVT for AIS-LVO

The purpose of this study is to determine the efficacy and safety of plasma adsorption for patients of acute ischemic stroke who underwent endovascular thrombectomy due to large vessel occlusion of anterior circulation.

Participants needed: 100
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: Yi YangUpdated: Jun 29, 2025Locations: 1
Eligibility criteria

Age 18-80 years, male or female. [+5]

Imaging after EVT indicated malignant brain edema with midline shift or brain he... [+11]

Status: Recruiting

iTBS for Acute Ischemic Stroke After Thrombectomy

The goal of this randomized, single-blind, parallel-controlled clinical trial is to evaluate the efficacy and safety of intermittent theta burst stimulation (iTBS) as an adjunctive therapy for acute anterior circulation ischemic stroke patients who have undergone successful mechanical thrombectomy (MT). The study population includes adults aged 18-85 with NIHSS scores 5-25 post-MT and eTICI≥2b reperfusion.

Participants needed: 178
Trial details
Age: 18-85Biological sex: AllType: InterventionalSponsor: Yi YangUpdated: Apr 30, 2025Locations: 1
Eligibility criteria

1) Age 18-85 years, regardless of gender. [+4]

1) Pre-stroke modified Rankin Scale (mRS) score ≥2. [+7]

Status: Not yet recruiting

Safety and Efficacy of Remote Ischemic Conditioning in Patients with Chronic Internal Carotid Artery Occlusion Receiving Hybird Surgery: a Pilot, Randomized Controlled Trial

The purpose of this study is to explore the safety and efficacy of remote ischemic conditioning in patients with internal carotid artery occlusion receiving hybird surgery.

Participants needed: 60
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Yi YangUpdated: Nov 26, 2024
Eligibility criteria

Age≥18 years, regardless of sex [+3]

Hemorrhagic stroke [+7]

Status: Not yet recruiting

Safety and Efficacy of Edaravone Dexborneol for Acute Ischemic Stroke

The purpose of this study is to determine the efficacy and safety of edaravone dexborneol in treating acute ischemic stroke.

Participants needed: 1,200
Trial details
Phase: Phase 4Age: 18-80Biological sex: AllType: InterventionalSponsor: Yi YangUpdated: Oct 17, 2024Locations: 1
Eligibility criteria

Age ≥ 18 years old and ≤ 80 years old, regardless of gender; [+5]

Reperfusion therapy (intravenous thrombolysis and endovascular therapy) has been... [+13]

Status: Not yet recruiting

Effects of rTMS on the Anxiety State of Older Patients With GAD

The purpose of this study is to evaluate the effects of low-frequency repetitive transcranial magnetic stimulation on anxiety state in older patients with generalized anxiety disorder.

Participants needed: 100
Trial details
Age: 60+Biological sex: AllType: InterventionalSponsor: Yi YangUpdated: Oct 2, 2024Locations: 1
Eligibility criteria

1)Age≥60 years, regardless of gender. [+4]

1)Traumatic brain injury or other conditions affecting the brain, such encephali... [+8]

Status: Recruiting

Effects of Remote Ischemic Conditioning on Blood Pressure in Older Patients With Hypertension

The purpose of this study is to learn about effects of remote ischemic conditioning on blood pressure in older patients with essential hypertension.

Participants needed: 158
Trial details
Age: 65-85Biological sex: AllType: InterventionalSponsor: Yi YangUpdated: Oct 2, 2024Locations: 1
Eligibility criteria

1) Age ≥65 years and ≤85 years, regardless of gender; [+2]

1) Secondary hypertension; [+8]

Status: Not yet recruiting

Effectiveness of Digital Health Management on Patients With Head and Neck Vascular Stenosis

The purpose of this study is to evaluate the effectiveness of digital health management for intervention on Chinese population with head and neck vascular stenosis.

Participants needed: 102,072
Trial details
Age: 35+Biological sex: AllType: InterventionalSponsor: Yi YangUpdated: Oct 2, 2024Locations: 1
Eligibility criteria

Inclusion criteria of the clusters [+5]

Exclusion criteria for the clusters [+3]

Status: Recruiting

Safety and Efficacy of Levofloxacin for Acute Ischemic Stroke

The purpose of this study is to determine the efficacy and safety of levofloxacin in treating acute ischemic stroke.

Participants needed: 100
Trial details
Age: 18-75Biological sex: AllType: InterventionalSponsor: Yi YangUpdated: Oct 2, 2024Locations: 1
Eligibility criteria

Age 18-75 years. [+3]

Patients with transient ischemic attack and those undergoing emergency reperfusi... [+10]

Status: Not yet recruiting

Safety and Efficacy Study of Levofloxacin Combined With Endovascular Thrombectomy for Acute Ischemic Stroke

The purpose of this study is to determine the efficacy and safety of levofloxacin combined with endovascular thrombectomy in treating acute ischemic stroke due to large vessel occlusion of anterior circulation.

Participants needed: 80
Trial details
Age: 18-75Biological sex: AllType: InterventionalSponsor: Yi YangUpdated: Oct 2, 2024
Eligibility criteria

Age 18-75 years. [+3]

Patients with contraindications to emergency thrombectomy; [+10]

Status: Not yet recruiting

Safety and Efficacy of Remote Ischemic Conditioning in Patients With Acute Ischemic Stroke

he purpose of this study is to determine the efficacy and safety of remote ischemic conditioning for acute ischemic stroke.

Participants needed: 912
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: Yi YangUpdated: Oct 2, 2024Locations: 1
Eligibility criteria

1)Age≥18 years, < 80 years, regardless of sex; [+4]

1) Patients with suspected posterior circulation infarction; [+17]

Status: Not yet recruiting

Safety and Efficacy of Remote Ischemic Conditioning in Patients With Spontaneous Intracerebral Hemorrhage

The purpose of this study is to determine whether treatment with remote ischemic conditioning is of sufficient promise to improve outcome before conducting a larger clinical trial to examine its effectiveness as a treatment for intracerebral hemorrhage.

Participants needed: 530
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Yi YangUpdated: Oct 2, 2024Locations: 1
Eligibility criteria

Age ≥ 18 years [+5]

Definite evidence of secondary ICH, such as structural abnormality, brain tumor,... [+14]

Status: Recruiting

Cerebral Autoregulation in Patients With Symptomatic Cerebral Atherosclerotic Stenosis

In this multi-center prospective observational study within a cohort of symptomatic cerebral atherosclerotic stenosis (sCAS) patients, 850 subjects were planed to be enrolled to explore the relationship between cerebral autoregulation (CA) and stroke recurrence, determine the threshold values of CA parameter for predicting stroke recurrence associated with particular stenosis.

Participants needed: 850
Trial details
Age: 18-80Biological sex: AllType: ObservationalSponsor: Yi YangUpdated: Mar 1, 2024Locations: 1Duration: 24 Months
Eligibility criteria

Age ranging from 18 to 80, both genders [+8]

Vertebral artery (VA), basilar artery (BA), anterior cerebral artery (ACA), or p... [+7]

Status: Recruiting

Application of Biomarkers in Neurological Diseases

To explore the predictive and diagnostic role of biomarkers in patients with neurological diseases.

Participants needed: 3,000
Trial details
Biological sex: AllType: ObservationalSponsor: Yi YangUpdated: Mar 1, 2024Locations: 1Duration: 1 Year
Eligibility criteria

Patients with neurological diseases; [+1]

Participating in other clinical investigators; [+2]

Status: Not yet recruiting

Effect of Ginkgo Biloba Extract on Cognitive Function in Acute Ischemic Stroke

The purpose of this study is to determine the effect of ginkgo biloba extract on cognitive function in acute ischemic stroke.

Participants needed: 356
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Yi YangUpdated: Feb 28, 2024
Eligibility criteria

Patients with a definitive clinical diagnosis of acute ischemic stroke; [+4]

Transient ischemic attack; [+12]

Status: Not yet recruiting

Safety and Efficacy of Urinary Kallidinogenase for Large Artery Atherosclerosis Acute Ischemic Stroke

The purpose of this study is to evaluate the safety and efficacy of urinary kallidinogenase treatment in patients with large artery atherosclerotic acute ischemic stroke.

Participants needed: 986
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Yi YangUpdated: Feb 28, 2024Locations: 1
Eligibility criteria

Age ≥18 years old; [+4]

Transient ischemic attack; [+11]