Changes in Hemodynamic Response Following Transcranial Electrical Stimulation in Sroke Individuals
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorMahidol University
About this trial
The present study will use transcranial electrical stimulation (tES) which are transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) combined with conventional physical therapy and cognitive-motor dualt ask gait training in sub-acute (at least 2 weeks after stroke onset) to chronic stroke (within 5 years post-stroke) to investigate changes in brain hemodynamics (oxy-hemoglobin and deoxy-hemoglobin concentration) as measured by functional near infrared spectroscopy (fNIRS). The findings may provides insights changes in combining tES with rehabilitation on improvements in brain hemodynamics in sub-acute to chronic stroke.
Eligibility criteria
Qualifiers
Unilateral stroke individuals aged 18-80 years.
A first-ever stroke.
Stroke onset from at least 2 weeks-5 years.
Able to walk independently with or without gait aids (modified Rankin scale (mRS) 1-3)
Disqualifiers
Presence of any psychological or neurological antecedent, unstable medical conditions or condition that may increase risk of stimulation such as epilepsy, seizure, and history of brain injury
Having unstable cardiovascular disease or respiratory disease, and uncontrolled chronic disease such as diabetes mellitus (DM), hypertension (HT) and chronic kidney disease (CKD)
Receiving other non-invasive brain stimulation or additional intervention such as TMS, PMS or acupuncture
Presence of metal implantation, intracranial shunt, cochlear implantation, or cardiac pacemakers.
Trial design
Treatments tested in this trial
- Transcranial direct current stimulation
- transcranial alternating current stimulation
- Rehabilitation program
- transcranial electrical stimulation (Sham)
Treatment groups
60 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov