Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age21+
SponsorCase Western Reserve University
About this trial
The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in subjects affected by severe periodontitis; to evaluate if microbiome changes in relation to the used of different implant material/surface; and to assess the variance of the changes to determine the sample size for future longitudinal prospective studies.
Eligibility criteria
Qualifiers
At least 21 years of age
Diagnosis of Stage III or IV periodontitis based on full mouth probing and full mouth x-rays
Planned for full mouth extraction and replacement by dental implants.
Rehabilitation with Implant supported restorations either maxilla and/ or mandible.
Disqualifiers
Conditions requiring chronic routine prophylactic use of antibiotics.
Conditions requiring prolonged use of steroids.
History of leukocyte dysfunction and deficiencies
Bleeding disorders
Trial design
Treatments tested in this trial
- Microbial Sampling
Treatment groups
12 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov