This is a single arm, interventional pilot study of using chlorhexidine irrigation intra-operatively and post-operatively among patients undergoing radical cystectomy with urinary diversion. The intervention comprises of using irrigation of ileal conduit or ileal neobladder intra-operatively and then for irrigation of either post-surgery with Irrisept ®. The sterilization of urine will be assessed at 10 days after cystectomy. Incidence of symptomatic urinary tract infections within the 30-day post-operative period will be estimated.
Provision of signed and dated informed consent form.
Stated availability for the duration of the study, and willingness to comply with all study procedures, including willingness to adhere to twice daily irrigation of neobladder or ileal conduit.
Male or female, ≥ 18 years of age
Confirmed diagnosis of bladder cancer
Has undergone or planned to undergo urinary diversion other than ileal conduit or neobladder.
Pregnancy or lactation.
Known allergic reactions to components of the Irrisept irrigating system, chlorhexidine.
Patient must not have any uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that, in the opinion of the investigator, would limit compliance with study requirements.
Icahn School of Medicine at Mount Sinai
Lead sponsor
Irrimax Corporation
Collaborator