Health Trials

Chrono-restricted Diet and Physical Activity as a New Preventive Strategy for Sarcopenia in Postmenopausal Women With Obesity and Type 2 Diabetes

ConditionsObesitySarcopeniaPost MenopauseType 2 DiabetesCircadian Clock
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age45-70
SponsorUniversity Hospital, Toulouse

About this trial

The aim of TIMEDIAB is to demonstrate that early TRE (eTRE) combined to late (afternoon) exercise will outperform eTRE combined to morning exercise on muscle function as primary endpoint, and glucose homeostasis as secondary endpoint

Eligibility criteria

Qualifiers

Post-menopausal women (amenorrhea for at least 12 months, confirmed by gonadotrophins measures)

Age range 45-70 years

T2DM diagnosed for more than 1 year

Subjects with T2DM treated with lifestyle control alone or associated with metformine ± DPP4 inhibitors

Disqualifiers

Subjects on T2DM injectable medication or drugs able to induce hypoglycemia (glinides, sulfonylurea)

Subjects with HbA1c > 8%

Congestive cardiac failure

Stage 4 chronic kidney disease (i.e. eGFR < 30 ml/min/1.73 m2)

Trial design

Treatments tested in this trial

  • Antidiabetic diet (control)
  • eTRE diet
  • Physical activity in the morning
  • Physical activity in the afternoon

Treatment groups

45 Participants
are divided into 3 treatment groups

Sponsors and collaborators

University Hospital, Toulouse

Lead sponsor

Source ClinicalTrials.gov