Color Change and Desensitization of Molar Incisor Hypomineralization-Affected Enamel Using Biomimetic Nano-Hydroxyapatite Toothpaste

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age6-12
SponsorKing Abdulaziz University

About this trial

This clinical trial aims to evaluate if nano-hydroxyapatite (Nano-HA) toothpaste effectively treats children with Molar-Incisor Hypomineralization (MIH). It will also assess the safety of Nano-HA toothpaste. The main questions are:

* Does Nano-HA toothpaste reduce caries incidence, improve tooth aesthetics, and decrease hypersensitivity? * How does Nano-HA compare to fluoridated toothpaste in terms of outcomes?

Participants will:

* Use Nano-HA or fluoridated toothpaste daily for 12 months. * Visit the clinic for checkups and evaluations every 1 to 3 months. * Record symptoms, brushing compliance, and sensitivity.

The study will compare Nano-HA toothpaste to fluoridated toothpaste to determine its efficacy in managing MIH .

Eligibility criteria

Qualifiers

Diagnosed with Molar-Incisor Hypomineralization (MIH) in at least one first permanent molar or hypomineralization of a second primary molar (HSPM).

Presence of white, creamy, yellow, or brown demarcated opacities

Indexed teeth include permanent first molars and permanent maxillary incisors.

Disqualifiers

• Decayed permanent molars.

Diabetes, hypertension, sleeping disorders, or allergic reactions to medications.

Children on medication

Presence of other enamel defects (e.g., fluorosis, amelogenesis imperfecta, enamel hypoplasia, or white spot lesions).

Trial design

Treatments tested in this trial

  • Fluoridated Toothpaste
  • Nano-hydroxyapatite Toothpaste

Treatment groups

60 Participants
are divided into 2 treatment groups

Sponsors and collaborators