Molar-Incisor Hypomineralization (MIH)

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Review clinical trials related to Molar-Incisor Hypomineralization (MIH). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Evaluation of Occlusal Force and Masticatory Function in Children With Molar-Incisor Hypomineralization

This study aims to evaluate right-left chewing balance and masticatory function in children with Molar-Incisor Hypomineralization (MIH) before and after restorative treatment. MIH is a developmental enamel defect that may cause tooth sensitivity, discomfort during chewing, and functional asymmetry. Children aged 7 to 12 years with bilateral MIH affecting the first permanent molars will receive glass hybrid restorative treatment. Right-left occlusal force distribution will be assessed using a digital occlusal analysis system. In addition, chewing side preference and chewing balance will be evaluated using a standardized chewing gum protocol. These two assessment methods will be used together to provide complementary information about masticatory function. Measurements will be performed before treatment and during follow-up visits after treatment. The findings obtained from children with MIH will also be compared with healthy children without MIH. The study aims to determine whether restorative treatment improves chewing balance and functional oral performance in children with MIH.

Participants needed: 68
Trial details
Age: 7-13Biological sex: AllType: InterventionalSponsor: Marmara UniversityUpdated: Jun 4, 2026
Eligibility criteria

Children aged 7 to 12 years [+6]

Temporomandibular disorders or orofacial pain [+6]

Status: Recruiting

Color Change and Desensitization of Molar Incisor Hypomineralization-Affected Enamel Using Biomimetic Nano-Hydroxyapatite Toothpaste

This clinical trial aims to evaluate if nano-hydroxyapatite (Nano-HA) toothpaste effectively treats children with Molar-Incisor Hypomineralization (MIH). It will also assess the safety of Nano-HA toothpaste. The main questions are: * Does Nano-HA toothpaste reduce caries incidence, improve tooth aesthetics, and decrease hypersensitivity? * How does Nano-HA compare to fluoridated toothpaste in terms of outcomes? Participants will: * Use Nano-HA or fluoridated toothpaste daily for 12 months. * Visit the clinic for checkups and evaluations every 1 to 3 months. * Record symptoms, brushing compliance, and sensitivity. The study will compare Nano-HA toothpaste to fluoridated toothpaste to determine its efficacy in managing MIH .

Participants needed: 60
Trial details
Age: 6-12Biological sex: AllType: InterventionalSponsor: King Abdulaziz UniversityUpdated: Feb 27, 2026Locations: 1
Eligibility criteria

Diagnosed with Molar-Incisor Hypomineralization (MIH) in at least one first perm... [+2]

• Decayed permanent molars. [+4]