Comparison of Chemoradiotherapy and Chemoradiotherapy Combined With Consolidation Chemotherapy for ESCC

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorThe First Affiliated Hospital with Nanjing Medical University

About this trial

This study is a phase III, multicenter, prospective randomized controlled clinical study comparing the efficacy of non-surgical esophageal squamous cell carcinoma with radical chemoradiotherapy and radical chemoradiotherapy combined with consolidation chemotherapy. The survival time and side effects of patients were observed and compared.

Eligibility criteria

Qualifiers

Age 18-70 years old, not limited to male or female; at least able to take liquid diet;

Esophageal squamous cell carcinoma proved by histopathology;

Esophageal squamous cell carcinoma that is inoperable or refuses surgery,

According to the 2017 8th edition of AJCC esophageal cancer new staging criteria, the tumor is T2N0M0-TxNxM0 stage;

Disqualifiers

History of malignant tumors in other parts;

Duplicate carcinoma of the esophagus;

Pregnant or lactating patients;

Fertility but not using contraceptive measures;

Trial design

Treatments tested in this trial

  • Consolidation chemotherapy (4 courses)
  • Concurrent chemotherapy (2 courses)

Treatment groups

1,216 Participants
are divided into 2 treatment groups