Cortical Excitability and Role of Non Invasive Brain Stimulation in ADHD and AUTISM
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age6-19
SponsorAssiut University
About this trial
This double-blind, randomized, sham-controlled clinical trial will evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on children and adolescents with attention-deficit/hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) and matched healthy controls. Participants aged 6-19 years will be assigned to active or sham rTMS protocols targeting the dorsolateral prefrontal cortex over 3 weeks, with assessment of changes in disorder-specific symptoms and cortical excitability. The study aims to determine the safety, feasibility, and preliminary efficacy of rTMS as a non-invasive neuromodulation approach in pediatric neurodevelopmental disorders.
Eligibility criteria
Qualifiers
Age 6-19 years.
ASD trial: DSM-5 diagnosis of ASD confirmed by CARS-2.
ADHD trial: DSM-5 diagnosis of ADHD confirmed by structured interview/CONORS
IQ ≥ 70.
Disqualifiers
Epilepsy or seizure history.
Metallic implants or devices incompatible with TMS.
Severe psychiatric comorbidity (e.g., psychosis).
Inability to tolerate TMS procedures.
Trial design
Treatments tested in this trial
- Active repetitive transcranial magnetic stimulation (rTMS)
- Sham repetitive transcranial magnetic stimulation (sham rTMS)
Treatment groups
80 Participants
are divided into 4 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov