The aim of this study is to compare the Competency of coupling of IPACK Block with Adductor Canal Block versus Adductor Canal Block Alone on Postoperative Pain after total knee replacement as well as Functional Recovery and Inflammatory Response and range of motion postoperatively.
Patients undergoing total knee replacement.
ASA physical status I to III
Sex (males and females).
Age 20 - 70 years.
Patients undergoing bilateral or revision total knee replacement.
ASA physical status more than III
Age less than 20 or older than 70
severe renal insufficiency ( Estimated Glomerular filtration rate eGFR < 15 mL/min/1.73 m2 ).