Driving Pressure Guided Mechanical Ventilation Versus Lung Protective Ventilation Among Patients Undergoing Elective Surgeries

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age16-80
SponsorRawalpindi Medical College

About this trial

Patient undergoing surgeries in general anesthesia require support of their breathing by ventilator. Different strategies can be used to manage breathing of the patient. Lung protective ventilation provides breathing at a set volume determined by patient ideal body weight, along with a set rate to maintain adequate breathing. The pressures in the lower airway are kept less than 30 cm of H20 while a pressure of 5cm of H20 is applied to prevent lung collapse. Recently to above mentioned regimen a driving pressure is added which is a difference between lower airway pressure and pressure applied to prevent lung collapse. Ventilatory settings are adjusted to keep this driving pressure less than 15 cm of H2O.

Eligibility criteria

Qualifiers

American Society of Anesthesiologists (ASA) class: I and II.

Elective laparoscopic surgeries requiring General Anesthesia and Mechanical ventilation

Patients receiving neuromuscular blockade during surgery.

Receiving Mechanical ventilation for at least 1h.

Disqualifiers

Pregnancy

Patients who had received mechanical ventilation of more than 1h in the previous 2 weeks.

Body mass index >35 kg/m2

Smokers and ASA class III and above.

Trial design

Treatments tested in this trial

  • Lung protective ventilation
  • Driving pressure guided ventilation

Treatment groups

70 Participants
are divided into 2 treatment groups

Sponsors and collaborators