Effect of Dexamethasone on Labour Induction in Term Pregnancies
ConditionLabor Induction
Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexFemale
Age18+
SponsorCairo University
About this trial
The aim of the study is to assess the effect of dexamethasone on labour induction in term pregnancies.
Primary outcome:
The interval between initiation of induction and beginning of the active phase of labour.
Secondary outcomes:
* Duration of active phase of labour (starting with cervical dilatation of 4-5 cm up to full cervical dilatation). * Duration of second stage of labour * Mode of delivery. * Fetal outcome.
Group A:
Will receive one dose of IM dexamethasone sodium phosphate 8 mg (2 mL).
Group B:
Will receive vaginal misoprostol 25 μg tablets every 6 h, up to 4 tablets, for a maximum duration of 24 h.
Group C:
Will receive one dose of IM dexamethasone sodium phosphate 8mg (2mL) with the first dose of vaginal misoprostol 25 μg tablets that will be given every 6 h, up to 4 tablets, for a maximum duration of 24 h.
Eligibility criteria
Qualifiers
Age > 18 years.
Nulliparous.
Vertex presentation.
Singleton pregnancy.
Disqualifiers
Indication for cesarean section e. g. Placenta previa, intrauterine growth retardation, non-vertex presentation and previous cesarean section.
Maternal medical disorders as diabetes mellitus and severe pre-eclampsia.
Preterm labour and preterm rupture of membranes.
Gestational age <39 weeks of gestation.
Trial design
Treatments tested in this trial
- Dexamethasone (Decadron) 8mg IM injection
- Misoprostol 25 mcg
- Both Misoprostol 25 mcg & Dexamethasone 8mg IM injection
Treatment groups
150 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov