Labor Induction

5

Review clinical trials related to Labor Induction. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Pain Control for Cervical Ripening Balloon

No standard of care exists for pain management during cervical ripening balloon placement. The purpose of this study is to evaluate if vaginal topical lidocaine reduces pain related to cervical ripening balloon placement during induction of labor.

Participants needed: 110
Trial details
Phase: Phase 2Age: 18+Biological sex: FemaleType: InterventionalSponsor: Beth Israel Deaconess Medical CenterUpdated: Mar 5, 2026
Eligibility criteria

Age ≥18 years [+6]

Allergy or sensitivity to lidocaine [+2]

Status: Not yet recruiting

The Effect of Reflexology on Time to Delivery During Induction of Labor

This prospective, randomized controlled trial evaluates the effect of reflexology on maternal anxiety, labor duration, and pain in women undergoing labor induction with an extra-amniotic balloon (EAB). Eligible participants are women with a singleton, term pregnancy, cephalic presentation, intact membranes, and a Bishop score \<6, without prior cesarean delivery or contraindications to vaginal delivery. Participants will be randomized to two groups: an intervention group receiving reflexology by a certified practitioner following EAB placement, and a control group receiving standard care. Maternal anxiety will be assessed using the State-Trait Anxiety Inventory (STAI) before and after the intervention. Labor duration and pain scores will also be recorded. The study plans to enroll 84 participants over two years. Reflexology is a safe, non-invasive complementary therapy, and this study aims to determine whether it provides measurable benefits during labor induction.

Participants needed: 84
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Wolfson Medical CenterUpdated: Dec 10, 2025
Eligibility criteria

Age of ≥18 years [+5]

Patients who had undergone a previous cesarean delivery [+2]

Status: Recruiting

Calcium Carbonate to Augment Labor Contractions

The investigators think that calcium carbonate can act as an assistive medication to improve contractions during labor.

Participants needed: 60
Trial details
Phase: Phase 4Age: 18+Biological sex: FemaleType: InterventionalSponsor: Weill Medical College of Cornell UniversityUpdated: Oct 23, 2025Locations: 1
Eligibility criteria

18 years or older [+6]

Unable to understand or read English [+15]

Status: Recruiting

Effect of Dexamethasone on Labour Induction in Term Pregnancies

The aim of the study is to assess the effect of dexamethasone on labour induction in term pregnancies. Primary outcome: The interval between initiation of induction and beginning of the active phase of labour. Secondary outcomes: * Duration of active phase of labour (starting with cervical dilatation of 4-5 cm up to full cervical dilatation). * Duration of second stage of labour * Mode of delivery. * Fetal outcome. Group A: Will receive one dose of IM dexamethasone sodium phosphate 8 mg (2 mL). Group B: Will receive vaginal misoprostol 25 μg tablets every 6 h, up to 4 tablets, for a maximum duration of 24 h. Group C: Will receive one dose of IM dexamethasone sodium phosphate 8mg (2mL) with the first dose of vaginal misoprostol 25 μg tablets that will be given every 6 h, up to 4 tablets, for a maximum duration of 24 h.

Participants needed: 150
Trial details
Phase: Early Phase 1Age: 18+Biological sex: FemaleType: InterventionalSponsor: Cairo UniversityUpdated: Aug 7, 2025Locations: 1
Eligibility criteria

Age > 18 years. [+5]

Indication for cesarean section e. g. Placenta previa, intrauterine growth retar... [+4]

Status: Recruiting

Pain Management With Virtual Reality Hypnosis

The latency phase corresponds to the first phase of the first stage of labour, during which the parturient feels regular, rhythmic uterine contractions that are often painful, with or without changes of the cervix. This phase lasts an average of 8 hours for primiparous women, compared with 5 hours for multiparous women, and can last up to twenty hours in total. Cervical ripening corresponds to the medical induction of regular, painful uterine contractions in order to obtain a favourable cervix for the induction of labour. Cervical ripening is carried out either medically (oral or local prostaglandins) or mechanically (double balloon dilatation) and accounts for 69.2% of labour inductions, which in turn account for 25.8% of births. At Amiens-Picardie University Hospital, this maturation stage can last from a few hours to 2 days, depending on the service protocol. What these two stages of childbirth have in common is that they are both painful, with very few analgesic drugs available that can be used without side-effects on the foetus during pregnancy. In recent years, there has also been a growing demand from parturients for the use of non-medicinal therapies. It therefore seems essential to provide parturients with as many effective non-drug methods as possible to manage their pain properly. If virtual reality hypnosis sessions prove to be effective, they will provide better pain management for women in labour, reduce the use of morphine derivatives (with their attendant side-effects, particularly on the foetus), and above all meet the growing demand from women in labour for the most physiological possible support during childbirth.

Participants needed: 142
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Centre Hospitalier Universitaire, AmiensUpdated: May 25, 2025Locations: 1
Eligibility criteria

Parturient over 18 [+9]

Parturient under legal protection [+12]