Relationship Between Remimazolam and Etomidate in Induction of General Anesthesia

Trial statusNot yet recruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18-60
SponsorSecond Hospital of Shanxi Medical University

About this trial

In modern anesthesia practice, anesthesiologists often need to choose a combination of multiple drugs according to the specific conditions and surgical needs of patients, which can not only achieve more fine anesthesia management, but also improve perioperative safety and patient comfort. In clinical practice, anesthesiologists will use etomidate combined with a small dose of remimazolam for anesthesia induction to obtain more stable hemodynamics, prevent intraoperative awareness, and relieve anxiety.However, what is the best dose ratio of etomidate combined with remimazolam, the current literature does not give clear indicators.

Eligibility criteria

Qualifiers

Both sexes

aged 18-60 yr

ASA physical status I-II

BIM: 18-28kg/m²

Disqualifiers

allergic to remimazolam and etomidate

in pregnancy or lactation

serious cardiovascular diseases, long-term alcoholism

used sedative drugs or opioids within 24 hours

Trial design

Treatments tested in this trial

  • Etomidate
  • Remimazolam
  • Remimazolam-etomidate

Treatment groups

125 Participants
are divided into 5 treatment groups