The goal of this observational study is to determine whether a clinically relevant dose of activated charcoal raises the serum osmolality and osmolal gap in a population of healthy volunteers. Secondarily to determine whether the same dose creates a false positive result using an enzymatic assay.
1. Does a clinically relevant dose of commercially available activated charcoal raise the osmolal gap above the baseline of a healthy volunteer? 2. Does the same dose of charcoal cause a false positive enzymatic assay for ethylene glycol?
Participants will be asked to consume a dose of activated charcoal and have serial blood draws for laboratory measurements.
Healthy adults
Any medical comorbidities
Recent illness
Pregnancy
Prisoners
Healthy volunteers
Cohort
Prospective
Activated Charcoal
DrugThis is the only intervention
Osmol Gap Change
Delta serum osmolality and osmolal gap at time points 0.5, 1, 2, 4, and 6 hours after Activated charcoal given
Ethylene Glycol
Numeric result of ethylene glycol testing (measured by glycerol dehydrogenase assay) before and after charcoal.
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