The purpose of this observational study is to understand the effect of gut microbiota on the efficacy of immunotherapy in patients with metastatic colorectal cancer and to explore the specific mechanisms of this process. In this way, it provides new ideas for the clinical treatment of colorectal cancer.
Clinical and pathological diagnosis of metastatic colorectal cancer
35-75 years old (both ends inclusive)
complete clinical information
signed informed consent
combined with severe respiratory and circulatory diseases
combined with other malignant tumors
recent severe active bleeding, uncontrolled active infection or active peptic ulcer
moderate to severe renal insufficiency